浓缩狂犬病疫苗接种后不良反应与血清抗体水平分析  

The Relationship Between Abnormal Reaction and Sero-Antibody Response to the Rabies Vaccine

作　　者：陆裕宽[1] 唐小萍 陆家华[1] 吴泰才[1] 李冲之 杜双兰 范培芳 

机构地区：[1]广西壮族自治区卫生防疫站 [2]深圳卫武光明生物制品厂 [3]山西省卫生防疫站

出　　处：《微生物学免疫学进展》1997年第1期36-39,共4页Progress In Microbiology and Immunology

摘　　要：报导了≥２．５ＩＵ浓缩狂苗人体接种后的不良反应其反应率为１．３１％与以往未浓缩常规苗的反应率为０．７３％比较两者具有显著性差异（Ｘ２＝６．９４，Ｐ＜０．０１），浓缩苗以注射１～３针时的不良反应多，临床表现以局部极痛、红肿、瘙痒、急性荨麻疹和过敏性休克等。但其血清抗体阳转率７天时为４０．０％以上，１４天时为１００％，而常规苗仅是４０．０％，抗体滴度浓缩苗第７天时达到有效保护水平（中和试验）。显示了其抗体产生早，水平高特点，关于如何减少浓缩狂苗不良反应问题。s The abnormal reaction and sero-antibody response to the concentrated (>=2.5 IU)and unconcentrated (ordinary) rabies vaccines has been observed.The abnormal reaction rate were 1.31% and 0.73% for the concentrated and unconcentrated respectively,the difference was statistically significant (X 2=6.94,P<0.01).The main clinic manifestation of the abnormal reaction,for the concentrated rabies vaccine were pain,swollen,itchy in the area of injection,and the acute urticaria even allergic shock.But the serotransverse rate for the concentrated vaccine reached above 40% within 7 days,100% within 14 days after vaccination compare with those of unconcentrated only 40% within 14 days. Still nore the antibody was sufficient enough to protect suffering from the rabies within 7 days after vaccination.lt indicates that the concentrated rabies vaccine characterized by its antibody emerged quickly and high level as well.It is also discussed how to reduce the abnormal reaction for the people whom received concentrated vaccine.

关 键 词：狂犬病疫苗 接种反应 不良反应 抗体水平 鉴定 

分 类 号：R512.990.3[医药卫生—内科学] R392－33[医药卫生—临床医学]