抗淋巴细胞球蛋白在HLA配型部分相合的造血干细胞移植患者的药代动力学  

Pharmacokinetics of the antilymphocyte globulin in recipients with partially HLA-matched hematopoientic stem cell transplantation

作　　者：张晓辉[1] 孟建波 黄晓军[1] 刘开彦[1] 许兰平[1] 刘代红[1] 陆道培[1] 

机构地区：[1]北京大学人民医院血液病研究所,北京100044 [2]河北医科大学第三临床医学院血液科,石家庄050000

出　　处：《中国临床药理学杂志》2007年第4期261-263,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的研究抗淋巴细胞球蛋白(ALG,免疫抑制剂)在HLA配型部分相合造血干细胞移植患者体内的药代动力学。方法14例患者应用ALG20mg.kg-1,连用4天;用酶联免疫吸附法检测ALG血药浓度,用3P97程序根据房室模型进行数据处理。结果AUC0-t为(1538.9±126.1)mg.h.L-1;Cmax为(369.8±21.0)mg.L-1,tmax为(4.5±0.4)d;t1/2β为(10.99±1.12)d;V/F(c)为(0.10±0.02)L.kg-1;CL(s)为(4.83±0.13)mL.d-1,ALG体内有效的血药浓度至少维持60天;ALG为超长半衰期药物,未出现严重药物不良反应。结论含ALG总剂量80mg.kg-1预处理方案,临床有效并安全,适宜在HLA配型部分相合的造血干细胞移植患者应用。Objective To investigate the pharmacokinetics of antilymphocyte globulin（ALG） in recipients of partially HLA -matched hematopoietic stem cell transplantation. Methods Forteen patients with hematological disorders were received hematopoietic stem cell transplantation. ALG was administered at a dose of 20 mg·kg^-1 daily for 4 consecutive days （ total of 80 mg · kg^- 1 ） in the conditioning regimen. The concentration of pig ALG in the serum of 14 patients was measured by a new enzyme - linked immunoabsorbent assay for IgG. Results The washout phase of ALG elimination was analyzed over 0～120 days. The pharmacokinetic paremeters were as follows ： t1/2β was （ 10.99 ±1. 12） days, V/F was （0.10±0.02） L·kg^-1,Cmax was （ 369.8±21.0） mg·L^-1, AUC0-1,was （1538.9 ±126.1） mg·h·L^-1;tmax was （4.5±0.4）d, CL（a） was （4.83±0.13 ）mL ·d^-1. No serious severe adverse effect was observed during the treatment with ALG, and could be tolerance. Conclusion The conditioning regimen containing the dosage of 80 mg of ALG is effective and safely in recipients with partially HLA - matched hematopoietic stem cell transplantation.

关 键 词：药代动力学 抗淋巴细胞球蛋白 酶联免疫吸附试验 配型不合造血 干细胞移植 

分 类 号：R969.1[医药卫生—药理学] R971.1[医药卫生—药学]