胰岛素无针粉末注射给药的降糖效果考察  

Hypoglycemic Effect of Insulin Powder Needle-free Injection on Diabetic Rabbits

作　　者：李伟[1,2] 周旭 王伽伯 金城 张萍 张薇[2] 肖小河 

机构地区：[1]解放军第302医院全军中药研究所,北京100039 [2]北京化工大学生命科学学院,北京100039北京化工大学生命科学学院北京100089 [3]不详

出　　处：《解放军药学学报》2007年第4期249-252,共4页Pharmaceutical Journal of Chinese People's Liberation Army

基　　金：国家"863"科技攻关项目重大专项基金;No.2004AA2Z3402;军队"十五"科研基金;No.01M205;首都医学发展重点项目基金;No.2002-2009

摘　　要：目的考察胰岛素无针粉末注射给药对糖尿病家兔的降血糖效果,为研制开发胰岛素无针粉末注射剂提供参考。方法36只四氧嘧啶致糖尿病家兔被随机分成6组,每组6只,空白粉末无针注射组、胰岛素无针粉末注射低剂量组(0.2mg.kg-1),中剂量组(0.4mg.kg-1),高剂量组(0.6mg.kg-1);皮下注射胰岛素溶液组(0.2mg.kg-1),作为阳性对照;皮下注射生理氯化钠溶液组,作为阴性对照。另外,6只正常家兔作为正常对照组。分别测定用药前后家兔的血糖值,并做组间分析比较。结果胰岛素无针粉末注射给药后,低剂量组血糖值下降到给药前的63.3%:中剂量组下降到给药前的43.8%;高剂量组下降到给药前的38.8%。皮下注射胰岛素后,血糖值下降到给药前的23.9%。胰岛素无针粉末注射给药的药理相对生物利用度低剂量组为42.1%,中剂量组为39.3%,高剂量组为34.3%。结论胰岛素无针粉末注射给药可有效降低糖尿病家兔的血糖。Aim To investigate the hypoglycemic effect on diabetic rabbits by using I-PNI and to provide reference for the development of I-PNI. Methods The following groups of diabetic rabbits which were treated with different dose of insulin and control groups were reviewed ： groupl （ I-PN1,0.2mg·kg^ - 1, n = 6） ; group2 （ I-PN1,0.4mg·kg^ - 1, n = 6） ; group3 （I-PNI,0.6mg·kg^ - 1, n =6）;group4（IMI,0.2mg·kg^ - 1, n =6）;blank control group（ n =6） and normal control group（ n = 6）. The blood glucose concentration was measured after treatment. Results （ 1 ） The blood glucose concentration of diabetic rabbits decreased after I-PNI; （2）After I-PNI, the blood glucose concentration of groupl decreased to 63.3% of the initial level;that of group2 decreased to 43.8% of the initial level and that of group3 decreased to 38.8% of the initial level. After IMI,the blood glucose concentration of group4 decreased to 23.9% of the initial level. （3）The relative pharmacological bioavailability of I-PNI was 42.1% （groupl） ;38.3% （groupl） and 34.3% （groupl）. Conclusion The I- PNI showed a significant hypoglycemic effect on diabetic rabbits.

关 键 词：无针粉末注射 胰岛素 家兔 糖尿病 

分 类 号：R965[医药卫生—药理学]