高效液相色谱法测定胃舒康颗粒中原儿茶醛的含量  

Determination of Protocatechuic Aldehyde in Weishukang Granules by HPLC

作　　者：王宝全[1] 王海龙[1] 赵庆华[1] 

机构地区：[1]济南军区联勤部药品仪器检验所,山东济南250022

出　　处：《解放军药学学报》2007年第4期313-315,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的建立胃舒康颗粒中原儿茶醛的含量测定方法。方法采用反相高效液相色谱法测定胃舒康中原儿茶醛的含量。采用SilC18色谱柱,以甲醇-1%醋酸(13∶87)为流动相,流速为1ml/min,检测波长280nm。结果原儿茶醛在0.0762～0.4572μg范围内线性关系良好,r=0.9999,平均回收率为100.6%,RSD为0.88%(n=6)。结论该方法简便、灵敏、准确,可作为胃舒康颗粒的质量控制方法。Aim To establish a method for the determination of protocatechuic aldehyde in Weishukang granules Methods RP-HPLC method was developed for the determination of protocatechuic aldehyde in Weishukang granules on the Japanese Sil C18 column, with methanol-1% acetic acid （13： 87） as a mobile phase （1ml/min） and detection wavelength at 280 nm. Results The linear range of Protocatechuic aldehyde was 0. 076 2 - 0. 457 2μg and the correlation coefficient was 0. 999 9. The average recovery rate was 100.6% , and RSD was 0.88% （ n = 6）. Conclusion The method is convenient, accurate and can be used to control the quality of granules.

关 键 词：HPLC 胃舒康颗粒 原儿茶醛 

分 类 号：R927.2[医药卫生—药学]