急性肺动脉栓塞血流动力学和血管活性物质的动态变化  

Hemodynamics and vasoactive substances in acute pulmonary vascular microembolism

作　　者：杨红申[1] 张向红[1] 潘文森[1] 张鲁涛[1] 马俊义[1] 

机构地区：[1]河北医科大学第二医院呼吸内科,石家庄050000

出　　处：《国际呼吸杂志》2007年第14期1059-1061,共3页International Journal of Respiration

摘　　要：目的 探讨急性弥漫性肺动脉栓塞血流动力学和血管活性物质动态变化。方法 健康家猪16只，随机分为实验组8只，对照组8只。经颈外静脉插管快速注入多聚乙烯微球栓子（0.1g/kg）制作猪急性肺动脉栓塞模型为实验组，而对照组仅注射0.9%生理盐水50ml。观察实验过程中血流动力学、内皮素-1（ET-1）和血栓素A2（TXA2）的代谢产物TXB2的动态变化。结果 多聚乙烯微球栓子可诱发急性肺动脉压升高，持续约1～2h。ET-1和TXA2分别于栓塞后0.5h和2h检测到浓度升高，在整个实验过程中持续在较高水平。结论 急性肺动脉栓塞时血流动力学动态变化和急性肺损伤是肺小动脉机械性栓塞和血管活性物质ET-1和TXA2共同作用的结果。Objective To investigate the change of hemodynamics and vasoactive substances in acute pulmonary embolism. Methods Sixteen heathy pigs were used, and divided into two groups, 8 pigs in experimental group and 8 pigs in control group. The experimental group received polysterene microbeads（0.1 g/kg） venouse injection and the control group received 50 ml of 0.9 % saline injection. The hemodynamics parameters were recorded before and after acute pulmonary embolism. The plasma endothelin-1（ET-1） and thromboxane A2 （TXA2） were examined at the same time. Results Polysterene microbeads venouse injection caused abrupt increasing of pulmonary arterial pressure and sustained for about 1-2 h. The increase of ET-1 and TXA2 was separately detected after 0. 5 h and 2 h in acute pulmonary embolised pigs,ET-1 and TXA2 maintained at a higher level during the experiment. Conclusions Hemodynamics change and lung injury in acute pulmonary vascular microembdism may be caused by both embolism mechanical obstruction and vasoactive substances such as ET-1 and TXA2.

关 键 词：急性肺动脉栓塞 内皮素-1 血栓素A2 

分 类 号：R563[医药卫生—呼吸系统]