系统性红斑狼疮病人血浆脂质过氧化物含量和红细胞超氧化物歧化酶活性的变化  

Measurement of Serum LPO and SOD Activities of Erythrocytes in patients with Systemic Lupus Erythematosus.

作　　者：张素英[1] 纪岩文[1] 陈宏[1] 崔平津 单书宝[2] 孙国敏[2] 纪志娟 梁浩[2] 

机构地区：[1]天津医科大学总医院皮肤科,300052 [2]天津医科大学总医院神经病学研究所生化室

出　　处：《中国皮肤性病学杂志》1997年第1期9-10,共2页The Chinese Journal of Dermatovenereology

摘　　要：总结 65例SLE病人血浆LPO含量及红细胞SOD活性的变化。活动期病人体内OR水平增高 ,以致SOD的活性下降 ,LPO含量增高 ;经类固醇治疗后的非活动期病人SOD的活性相对增高 ,LPO含量减少 ,提示体内OR水平下降。紫外线照射和某些药物能够激活嗜中性白细胞释放过多的OR 。Serum lipid peroxied(LPO) levels and activities of superoxide dismutase (SOD) of erythrocytes were measured in 65 patients with systemic lupus erythematosus(SLE).Oxygen radicals (OR) levels were significantly increased in active SLE patients while SOD activities were markedly decreased,LPO levels were increased.The gradual increase in SOD activities and decline in LPO levels were observed in inactive patients after treatment with corticosteroid suggesting a reduced OR level.Ultroviolet light and some medications could stimulate neutrophils to generate excessive OR that could enhance the autoimmune reaction.

关 键 词：SLE 红斑狼疮 脂质地氧化物 超氧化物歧化酶 

分 类 号：R593.241[医药卫生—内科学]