八氯二丙醚生产工人p53蛋白及氧化损伤检测  

Detection of serum p53 protein and oxidative damage in octachlorodipropyl-ether exposed population

作　　者：唐萌[1] 曾垂焕[1] 王波[1] 熊丽林[1] 王晓娜[1] 夏婷[1] 

机构地区：[1]东南大学公共卫生学院,南京210009

出　　处：《中国公共卫生》2007年第8期964-965,共2页Chinese Journal of Public Health

基　　金：江苏省预防医学基金项目(Y200421);东南大学科技基金项目(XJ019005)

摘　　要：目的检测八氯二丙醚生产工人氧化损伤及血清p53蛋白表达情况。方法选择暴露于八氯二丙醚工人21名为研究对象,另选21名非暴露者为对照,进行血清p53蛋白及丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的测定。结果暴露于八氯二丙醚工人血清p53蛋白水平略高于对照组,但工龄>8年组血清p53蛋白的水平显著高于工龄<8年组,差异有统计学意义(P<0.01);SOD、GSH-Px酶活性略低于对照组,MDA水平则显示升高(P<0.01)。结论长期暴露接触于八氯二丙醚作业工人可有p53基因异常的危险性,以及对氧化性应激的易感性。Objective Serum p53 protein expression and oxidative damage were detected in population exposed to octachlorodipropyl ether （S2）. Methods 21 workers occupationally exposed to S2 were selected as exposed group, and 21 workers without any exposure to chemical toxicants and other hazards served as the control group ; p53 protein, MDA, and activities of SOD, GSH - Px in serum were detected in two groups. Results Serum p53 protein expression of the exposure group was significantly higher than that of the control group when stratified by working age; MDA of the exposure group was significantly higher than that of the control group, but the activities of SOD, GSH - Px of the exposure group were lower than those of the control group without statistical significance. Conclusion Exposure to S2 could lead to mutation of p53 gene and oxidative damages.

关 键 词：八氯二丙醚 氧化损伤 P53蛋白 

分 类 号：R113[医药卫生—公共卫生与预防医学]