原癌基因Ki-ras在寻常性银屑病患者皮损表皮中的表达  

The Expression of Ki- ras Protooncogene in Psoriatic L esion.

作　　者：周利平[1] 胡长发[1] 张建平[1] 肖征[1] 闫鸣[1] 

机构地区：[1]武汉市第一医院皮肤科,430022

出　　处：《中国皮肤性病学杂志》1997年第2期69-70,共2页The Chinese Journal of Dermatovenereology

摘　　要：运用细胞原位杂交的方法 ,对 16例寻常性银屑病患者及 10例正常人皮肤中原癌基因 Ki-ras的表达进行了观察。结果表明 ,Ki- ras在所有被检测的表皮中均有表达 ,而在银屑病皮损表皮中的表达高于正常人对照 ( P<0 .0 1)。提示原癌基因 Ki-By means of cell in situ hybridization we carefully observed the expression of Ki- ras protooncogene in sixteen cases with psoriasis vulgaris and ten normal controls.Our results showed that Ki- ras pro- tooncogene was expressed in all epidermis.The expression in psoriatic lessions was higher than that in normal skin( P<0 .0 1) .It indicated that Ki- ras protooncogene may play an important role in the prolif- eration of psoriatic epidermis.

关 键 词：银屑病 原癌基因 KI-RAS 病理 

分 类 号：R758.630.2[医药卫生—皮肤病学与性病学]