超顺磁性氧化铁纳米粒子的制备及性能检测  

Preparation and performance testing for super-paramagnetic contrast agent of magnetic resonance

作　　者：柏玮[1] 宋琳[1] 文明[2] 李少林[1] 李必波[3] 彭志平[1] 

机构地区：[1]重庆医科大学基础医学院放射医学教研室 [2]重庆医科大学附属第一医院放射科 [3]重庆医科大学药学院药化教研室,重庆400016

出　　处：《重庆医科大学学报》2007年第9期922-925,共4页Journal of Chongqing Medical University

基　　金：重庆市卫生局医学科研项目(编号062025);重庆医科大学优秀博士基金(重医大2006-182号文)

摘　　要：目的:制备超顺磁性磁共振对比剂四氧化三铁纳米颗粒,并检测其物理和磁学性质,以探讨作为反义基因载体的可能性。方法:共沉淀一步法制备葡聚糖包被的四氧化三铁纳米颗粒,采用X射线粉末衍射法分析其结构,用透射电镜及原子力显微镜测量其大小及分布,用振动样品磁强计检测磁化率等参数。结果:所得样品核心为四氧化三铁晶体,核心粒径为5nm左右,包被葡聚糖后整体颗粒直径为20～35nm,驰豫率为0.155×106(/mol.s),质量饱和磁场强度为69.42162emu/g Fe。结论:制备的样品具有粒径小,分散性好,超顺磁性等优点,符合作为磁共振对比剂的要求,可以作为磁共振成像反义基因载体。Objective：To explore the possibility as antisense gene carriers. Preparation of super paramagnetic iron oxide MR contrast agent Iron oxide nanoparticles and test their physical and Magnetic Properties. Methods：the iron oxide nanoparticles is obtained by means of Co-precipitation method,its structure is analyzed by X-ray powder diffraction method,its size and distribution is measured by transmission electron microscope, and its Susceptibility is measured by Vibrating Sample Magnetometer dollars. Results：Testing after dextran-coated particle diameter overall,the size is 20-35nm,core diameter of around is 5nm,These particles possessed some characteristics of super paramagnetic. Relaxation rate Of the sample is 0.155×10^6/（mol·see） and quality saturation magnetic intensity is 69.42162emu/g Fe. Conclusion：the sample possessed the advantages of small size,dispersed ,super-paramagnetic,so it could be used as an anti-gene carriers.

关 键 词：超顺磁性氧化铁 磁共振成像 对比剂 纳米粒子 

分 类 号：R811.3[医药卫生—放射医学]