血清尿酸、C-反应蛋白与冠状动脉病变  

A study on the relationship among serum uric acid, serum C-reactive protein and the coronary lesions

作　　者：邓昌明[1] 黄晶[1] 刘地川[1] 江永红[1] 朱悫[1] 罗开良[1] 

机构地区：[1]重庆医科大学附属第二医院心血管内科,重庆400010

出　　处：《重庆医科大学学报》2007年第9期954-955,973,共3页Journal of Chongqing Medical University

基　　金：重庆市卫生局科研基金资助项目(渝卫科教2005-31);重庆市自然科学基金(项目编号:CSTC2006BB5280)

摘　　要：目的:探讨血尿酸、C-反应蛋白与冠状动脉病变关系。方法:将176例行冠状动脉造影患者分为冠状动脉病变组(Ⅰ组)和非冠状动脉病变组(Ⅱ组),分别检测血清尿酸和C-反应蛋白浓度,观察变化规律,探讨血清尿酸、C-反应蛋白与冠状动脉病变关系。结果:Ⅰ组血清尿酸、C-反应蛋白明显升高,并且血清尿酸、C-反应蛋白与冠状动脉狭窄病变Gensini积分明显相关(r分别为0.38,0.42,P<0.01)。结论:冠状动脉病变患者血清尿酸、C-反应蛋白明显增高,血清尿酸、C-反应蛋白在冠状动脉病变发生发展中起重要作用。Objective：We study on the relationship among the concentration of serum uric acid,the concentration of serum C-reactive protein and the severity of coronary lesions. Methods：176 patients were divided into two groups （group Ⅰ ：coronary artery lesions group and group Ⅱ ：non-coronary artery lesions group） by coronary angiography,the concentration of serum uric acid and serum C-reactive protein were measured in each patients, the relationship among the severity of coronary lesinns and the concetration of serum uric acid,the concetration of serum C-reactive protein were analysed by liner-correlated analysis. Results： the concentration of serum uric acid and serum C-reactive protein were increased in the groupⅠ , the concetration of serum uric acid and serum C- reactive protein correlated with Gensini scores. Conclusion：The results suggest that the increased serum uric acid and C-reactive protein play important role in the formation and development of coronary artery disease.

关 键 词：冠状动脉病变 尿酸 C-反应蛋白 冠状动脉造影 

分 类 号：R541.4[医药卫生—心血管疾病]