甲亢患者血清CG测定的意义  

The clinical significance of measurement of serum cholyglycine in patients with hyperthyroidism

作　　者：陶林[1] 李建国[1] 段东[1] 朱玉泉[1] 

机构地区：[1]重庆医科大学附属第一医院核医学科,重庆400016

出　　处：《重庆医科大学学报》2007年第8期869-870,共2页Journal of Chongqing Medical University

摘　　要：目的:探讨甲亢患者血清CG测定在评价甲亢性肝功能损害中的价值。方法:采用RIA方法测定50例健康志愿者及195例甲亢患者血清CG水平,并对谷丙转氨酶(ALT)进行同步检测,进行对比分析。结果:血清CG水平:甲亢初诊组与未缓解组明显高于对照组及甲亢治愈组(P<0.01),甲亢未缓解组明显高于初诊组(P<0.01),甲亢治愈组与对照组无显著性差异(P>0.05);CG的改变与ALT改变一致,且血清CG水平与甲状腺激素水平具有良好的相关性(相关系数为0.91)。结论:血清CG是评价甲亢性肝功能损害敏感而特异的指标。其增高的水平与甲亢病情及病程呈正相关。Objective：To study the clinical value of measurement of serum cholyglycine（CG）in the patients with hyperthyroidism to evaluate thyrotoxic hepatic damages. Methods：The levers of serum CG and ALT of 50 healthy volunteers （as control group） and 195 patients with hyperthyroidism were measured by radioimmunassay（RIA）. Results：Serum CG levels in the patients with hyperthyroidism （including the preliminary diagnosis group and unrelieved group）were distinctly higher than those in control group and cured hyperthyroidism group （P〈0.01）;it was distinctly higher in unrelieved group than that in preliminary diagnosis group with hyperthyroidism （P〈0.01）,and there was no distinct difference between the control group and cured hyperthyroidism group in serum CG （P〉0.05）. The change of serum CG was accordant with ALT. There was favourable correlation between the serum CG and serum thyroxine. Conclusion：Serum CG is a sensitive and specific index to evaluate the thyrotoxic hepatic damages,and the level of serum CG is correlative with the disease course and the level of serum thyroxine.

关 键 词：甲亢 甘胆酸 肝脏 肝功能 

分 类 号：R581[医药卫生—内分泌]