大剂量维生素C和地塞米松治疗猫急性颅脑伤的对照实验研究  

Experimental Study on Large-Dose Vitamin C and Large-Dose Dexamethasone in the Treatment of Head Injuried Cats

作　　者：刘子生 张加光 朱诚 张光霁[1,2,3,4] 王成海 

机构地区：[1]济南部队总医院神经外科 [2]山东省临邑县中医院外科 [3]上海长征医院神经外科 [4]第二军医大学神经生物教研室

出　　处：《中国冶金工业医学杂志》1997年第1期3-6,共4页Chinese Medical Journal of Metallurgical industry

摘　　要：目的：探讨大剂量维生素Ｃ对急性颅脑伤的治疗效果。方法：以自由落体法致猫脑挫伤后分组静脉滴注维生素Ｃ（２００ｍｇ／ｋｇ）和地塞米松（５ｍｇ／ｋｇ），测定血浆和脑脊液中ＡＶＰ和Ｄｙｎ－Ａ含量的变化，对挫伤区脑组织进行光镜和电镜观察。结果：维生素Ｃ治疗组动物脑创伤区病理改变明显好于颅脑伤组，脑含水量、颅内压以及血浆和脑脊液中ＡＶＰ和Ｄｙｎ－Ａ的含量均显著低于颅脑伤组，与大剂量地塞米松组相比，脑含水量亦显著降低。结论：大剂量维生素Ｃ治疗急性颅脑伤与大剂量地塞米松治疗效果相当，而且在降低脑水肿方面优于地塞米松。Objective:Large-dose vitamin C in treating head injuried were performed.Methods:The animals were rendomly divided into four groups,and the cerebral contusion were produced by the same method of freely falling body.A dose of 2oomg/kg of vitamin C and 5 mg/kg of dexamethasone were respectively injected intravenously at the moment and 6 hours after injury.The neuropetides were measured in CSF and serum.The traumatized cerebral tissues were studied under light microscope and electron microscope.Results:Brain water content,neuropeptides in CSF and serum were significantly lower in vitamin C group than in head-injuried group.Conclusions:Large-dose vitamin C could reduce second brain damage and brain edema after head injury,and could be used clinically.

关 键 词：颅脑伤 急性 维生素C 大剂量 猫 治疗 

分 类 号：R651.150.5[医药卫生—外科学]