新药 ST93-1 抗运动病效果的试验观察  

Experimental observation on anti motion sickness effects of the new drug ST93 1.

作　　者：裴静琛[1,2] 汤洛湘 孙桂菊[1,2] 尹庚寅[1,2] 杨天德 常磊 邢磊[1,2] 

机构地区：[1]航天医学工程研究所 [2]防化研究院第四研究所

出　　处：《中华航空航天医学杂志》1997年第1期5-9,共5页Chinese Journal of Aerospace Medicine

基　　金：国防科技跨行业基金

摘　　要：目的观察新药ＳＴ９３－１对正常人前庭－植物神经反应的影响，比较ＳＴ９３－１与东莨菪碱的抗运动病效果。方法１５名健康男性志愿者，在平行秋千摆动（摆长６ｍ，摆角４５°，频率０．２２Ｈｚ）刺激下诱发出运动病。运动病症状严重程度用Ｇｒａｙｂｉｅｌ运动病症状数字评分法评定；测定心率、皮肤温度。采用自身对照、双盲和安慰剂技术，以３－拉丁方排列顺序服药。在试验前３０ｍｉｎ分别口服ＳＴ９３－１２ｍｇ，东莨菪碱１ｍｇ和乳糖（安慰剂）。二次服药间隔７天～１０天。结果ＳＴ９３－１的保护率８０％，比东莨菪碱保护率高（７３．３％）；从秋千摆动刺激的耐受时间和运动病症状分值看，新药ＳＴ９３－１、东莨菪碱与安慰剂相比较有明显差异（Ｐ＜０．０５）。而ＳＴ９３－１的副作用比东莨菪碱少。ＳＴ９３－１对体温没有明显影响，对心率有调节作用。结论新药ＳＴ９３－１是一种副作用小、有效的抗运动病药。Objective To observe the influence of the new drug ST93 1 on vestibular autonomic nerve reaction and compare its anti motion sickness effects with scopolamine. Methods Fifteen healthy male volunteers were subjected to parallel swing swinging stimulus to induce motion sickness (MS) symptoms (arm length 6 m, angular deflection 45°, frequency 0.22 Hz). Severity of MS symptoms was scored in terms of Graybiel's criteria.Heart rate and skin temperature were recorded. The ST93 1(2 mg), scopolamine(1 mg) and placebo were administered 30 minutes prior to each test. Self control and double blind technique as well as 3 unit latin square design were employed in the experiment. The interval between two tests was 7～10 days to avoid adaptation. Results The protection index of ST93 1(80%) was higher than that of scopolamine(73%). The tolerance duration to swing stimulus and scores of MS symptoms for ST93 1 and scopolamine were significantly different from placebo ( P <0.05) , while the side effects of ST93 1 were less than those of scopolamine. The ST93 1 played an important role in regulation of heart rate, but it had no great influence to skin temperature. Conclusion The new drug ST93 1 is an effective medicine for anti motion sickness with less side effects.

关 键 词：运动病 东莨菪碱 抗运动病药物 药物疗法 

分 类 号：R852.330.5[医药卫生—航空、航天与航海医学]