复合环境因素对人心功能的影响  

Effects of combined stresses on cardiac function.

作　　者：虞学军[1] 陈景山[1] 贾司光[1] 张宝兰[1] 

机构地区：[1]航天医学工程研究所

出　　处：《中华航空航天医学杂志》1997年第1期43-47,共5页Chinese Journal of Aerospace Medicine

摘　　要：目的观察缺氧、温度、振动和噪声复合作用对人循环系统功能的影响。方法选２４名男性健康青年，按正交实验设计１４４人次，不同环境因素、不同强度组合成的试验条件。观察受试者心率（ＨＲ）、心输出量（ＣＯ）的变化。结果缺氧是显著影响ＨＲ、ＣＯ的主要因素，且对ＨＲ的影响最直接。较强振动与轻度缺氧复合作用呈拮抗作用；与严重缺氧呈协同作用；与中度缺氧交互作用不显著。较高的温度与轻度缺氧和严重缺氧复合作用时，具有加大ＣＯ的协同作用；与中度缺氧复合作用时较常温与中度缺氧的复合作用，ＣＯ显著减少，表现为拮抗作用。轻度缺氧与较强振动和常温三者的组合，具有降低缺氧引起ＣＯ增加的拮抗作用；严重缺氧与振动和温度三者的组合存在协同作用。结论复合因素作用下人体协同或拮抗的生理调节方式引起协同或拮抗的生理效应。Objective To explore effects of combined stresses (hypoxia,heat, noise and vibration) on cardiac function of human beings. Methods Twenty four healthy youngmen served as subjects.One hundred and forty four tests were carried out in orthogonal block design to arrange combined stresses of four factors. Multivariate statistical analysis to the measurements of cardiovascular system shows that hypoxia is the main factor to affect remarkably on heart rate(HR) and cardiac output(CO). Stronger vibration(SV,0.8 rms G Z, 40 Hz) combined with(×) mild hypoxia(MH, simulated altitude 3 km ),shows antagonistic effect on the increment of HR, while SV×SH (serious hypoxia,simulated altitude 6 km)displays a synergic one and IH (intermediate hypoxia,simulated altitude 4～5 km)×SV gives no interaction. Higher temperature (HT,40℃) extends the amount of CO synergically when combined with MH or SH. IH×HT lessens CO antagonistically compared with IH×AT(air temperature,25℃).MH×SV×AT reduces CO antagonistically contrasting to the increment of CO affected by hypoxia alone; but SH×SV×AT acts synergically. Conclusion The results suggest that synergical or antagonistical effect of combined factors results from their synergical or antagonistical regulation in human body.

关 键 词：复合应激 缺氧 热 噪声 振动 心率 心输出量 

分 类 号：R852[医药卫生—航空、航天与航海医学]