盐酸米诺环素微球凝胶的制备及对大鼠实验性牙龈炎的抑制作用  

A study on the preparation of biodegradable chitosan thermosensitive hydrogel for minocycline-HCl gelatin microspheres and its effects on experimental rats gingivitis

作　　者：王荣[1] 马志伟[2] 王晓娟[1] 王勤涛[2] 陈悦[2] 常晓亮[1] 

机构地区：[1]西安第四军医大学口腔医院药剂科,710032 [2]西安第四军医大学牙周黏膜病科

出　　处：《实用口腔医学杂志》2007年第4期503-506,共4页Journal of Practical Stomatology

基　　金：陕西省科学技术研究发展计划项目(编号:2006K14-G3)

摘　　要：目的:制备含盐酸米诺环素微球的功能性壳聚糖温敏凝胶,并观察载药凝胶对大鼠牙龈炎模型的抑菌效果。方法:将小分子药物盐酸米诺环素先制备成微球,共混于温敏凝胶中,观察其理化性质及释药性能;建立大鼠的实验性牙龈炎模型,观察载药凝胶对实验性牙龈炎模型的消炎效果。结果:实验制得的缓释凝胶,T50%可延长至4.24d;动物实验初步结果显示,与对照组相比实验组的牙龈指数和探诊深度有明显的减少,炎症细胞浸润数量少,毛细血管扩张程度轻。结论:加载盐酸米诺环素的缓释凝胶对大鼠实验性牙龈炎有一定的消炎作用。Objective： To prepare a functional chitosan thermosensitive hydrogel for minocycline-HC1 gelatin microspheres and observe its effects on repairing experimental rats gingivitis. Methods： Minocycline-HC1 gelatin microspheres were prepared by using gelatin as core material and emulsion crosslinking method, then the latter was incorporated into the chitosan thermosensitive hydrogel. Established an experimental gingivitis model in SD rats and to observe the effect of hydrogel on gingivitis. Results： Microspheres thermosensitive hydrogel had obviously sustained effects on gingivitis. Results showed that GI, PD in experiment group were significantly improved. Conclusion： The chitosan thermosensitive hydrogel loading of minocycline-HC1 gelatin microspheres have antiphlogistic effects on experimental rats gingivitis,

关 键 词：米诺环素 明胶微球 温敏凝胶 大鼠 牙龈炎 

分 类 号：R944[医药卫生—药剂学] R96[医药卫生—药学]