西苏格兰冠心病一级预防研究中端粒长度、冠心病风险和他汀类药物治疗:一项巢式病例对照研究  

Telomere length, risk of coronary heart disease, and statin treatment in the West of Scotland Primary Prevention Study:a nested case-control study

作　　者：Brouilette S.W. Moore J.S. McMahon A.D. N.J. Samani 奚群英 

机构地区：[1]Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom Prof.

出　　处：《世界核心医学期刊文摘（心脏病学分册）》2007年第7期10-11,共2页

摘　　要：背景：生物学衰老的个体差异可影响对冠心病的易感性。本研究旨在明确平均白细胞端粒长度是否为冠心病的预测因素。方法：比较西苏格兰冠心病一级预防研究（WOSCOPS）中纳入的484例后来发生冠心病事件的个体和1058例与之匹配的无冠心病事件个体的端粒长度。并探讨WOSCOPS研究中端粒长度与观察到的他汀类药物治疗临床益处是否存在联系。结果：对照组中，年龄每增长10岁平均端粒长度随之减少9％（95％CI3．6％～14．1％，P：0．001）；在病例组中，有大致相同的趋势（每10岁-5．9％，95％CI-3．1％～14．4％，P=0．1902）。Background： Inter-individual differences in biological ageing could affect susceptibility to coronary heart disease. Our aim was to determine whether mean leucocyte telomere length is a predictor of the development of coronary heart disease. Methods： We compared telomere lengths at recruitment in 484 individuals in the West of Scotland Primary Prevention Study（WOSCOPS） who went on to develop coronary heart disease events with those from 1058 matched controls who remained event free. We also investigated whether there was any association between telomere length and observed clinical benefit of statin treatment in WOSCOPS.

关 键 词：冠心病事件 端粒长度 巢式病例对照研究 预防研究 药物治疗 苏格兰 他汀类 WOSCOPS 

分 类 号：R587.2[医药卫生—内分泌]