冠心病患者冠状动脉循环中的血清内皮抑素及其与冠状动脉侧支形成的关系  

Serum Endostatin in the Coronary Circulation of Patients With Coronary Heart Disease and Its Relation to Coronary Collateral Formation

作　　者：Mitsuma W. Kodama M. Hanawa H. 黄欣 

机构地区：[1]Division of Cardiology, Department of Community Preventive Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan Dr.

出　　处：《世界核心医学期刊文摘（心脏病学分册）》2007年第7期21-21,共1页

摘　　要：内皮抑素在冠心病（CHD）中的作用尚不十分明确。本研究旨在探讨CHD患者中内皮抑素这一血管生成抑制因子在冠状动脉循环中的动力学，并阐明其与冠状动脉侧支形成的关系。纳入了72例疑似CHD或曾诊断CHD的受试者。在冠状动脉血管造影时采集患者左室（LV）腔和冠状窦（CS）血样，使用酶联免疫吸附测定试剂盒测定内皮抑素血清浓度。其后将患者分为两组：正常组（n=15），其定义为具有不典型胸痛、无器质性心脏病证据的患者组；CHD组（n=57），其定义为冠状动脉血管造影示冠状动脉狭窄≥75％且有劳力性胸痛的患者组。The role of endostatin in coronary heart disease（CHD） is not well known. This study aimed to investigate the dynamics of endostatin, an antiangiogenic growth factor, within the coronary circulation and to elucidate its relation to coronary collateral formation in patients with CHD. We recruited 72 subjects with suspected or previously diagnosed CHD. Blood samples from the left ventricular（LV） cavity and coronary sinus（CS） were obtained during coronary angiography, and the serum concentration of endostatin was measured by enzyme-linked immunosorbent assay kits. Patients were then divided into 2 groups： the normal group（n = 15） defined as patients with atypical chest pain and no evidence of organic cardiac diseases and the CHD group（n = 57） defined as patients with ≥ 75% coronary stenosis at coronary angiography and chest pain on exertion.

关 键 词：冠状动脉侧支 冠状动脉循环 冠心病患者 内皮抑素 血清浓度 冠状动脉血管造影 酶联免疫吸附测定 血管生成抑制因子 

分 类 号：R542.22[医药卫生—心血管疾病]