合并心力衰竭和(或)左室功能障碍的心肌梗死患者中的二尖瓣反流:预后意义及其与左室大小和功能的关系  

Mitral regurgitation in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both:Prognostic significance and relation to ventricular size and function

作　　者：Amigoni M. Meris A. Thune J.J. 刘少伟 

机构地区：[1]Brigham and Women’s Hospital, Boston, MA, United States

出　　处：《世界核心医学期刊文摘（心脏病学分册）》2007年第7期47-47,共1页

摘　　要：目的：二尖瓣反流（MR）是急性心肌梗死患者的独立危险因素。用来自VALIANT（缬沙坦在急性心肌梗死中的应用）超声研究的数据来分析基线MR与左室（LV）大小、形状和功能之间的关系，并评估基线MR及MR进展和心血管（CV）预后间的关系。方法和结果：研究了496例在心肌梗死（MI）后中位期5d接受超声心动图检查的合并心力衰竭（HF）和（或）收缩功能障碍的MI后患者。分别在基线、MI后1个月和MI后20个月时检测MR严重程度（通过反流喷射面积／左房面积比值定量），将该指标与LV大小、形状、功能和临床预后进行相关性分析。Aims： Mitral regurgitation（MR） confers independent risk in patients with acute myocardial infarction. We utilized data from the VALsartan In Acute myocardial iNfarcTion echo study to relate baseline MR to left ventricular（LV） size, shape, and function, and to assess the relationship between baseline MR and progression of MR and cardiovascular（CV） outcomes. Methods and results： We studied 496 patients with heart failure（HF） and/or systolic dysfunction after MI who underwent echocardiography at a median of 5 days after MI. MR severity, quantified as the regurgitant jet area/left atrial area ratio, was assessed at baseline, one and 20 months post-MI and related to LV size, shape, function, and clinical outcomes. Increased MR at baseline was associated with larger LV end-diastolic and end-systolic volumes, increased sphericity index, and reduced ejection fraction（P trend 〈0. 001）

关 键 词：心肌梗死患者 二尖瓣反流 左室大小 预后意义 心力衰竭 左室功能障碍 超声心动图检查 急性心肌梗死 

分 类 号：R473.5[医药卫生—护理学]