HBsAg阳性母亲的婴儿乙肝疫苗免疫效果评价  

Evaluation of Immune Effectiveness of Serum Hepatitis Vaccine in Infants Born to Single HBsAg Positive Mothers

作　　者：刘延菊[1] 曹明耀[1] 安文茜[2] 高艳霞[2] 

机构地区：[1]河北工程大学医学院,河北邯郸056029 [2]邯郸市妇幼医院,河北邯郸056001

出　　处：《河南科技大学学报（医学版）》2007年第2期100-101,共2页Journal of Henan University of Science & Technology:Medical Science

基　　金：河北省邯郸市科技局基金项目(200610808-7)

摘　　要：目的探讨HBsAg阳性母亲的婴儿乙肝疫苗免疫的最佳时机。方法将孕期检测HBsAg单阳性的母亲所产的健康婴儿65例,分为对照组和实验组,分别于出生后24 h内、3月龄时开始乙肝疫苗0,1,6月3针免疫,全程免疫后1、6、12、24个月时以R IA法检测抗-HBs滴度。结果3月龄时开始免疫组全程免疫后1、6、12、24个月时抗-HBs滴度均高于出生后24 h内免疫组。结论HBsAg单阳性的母亲所产的健康婴儿3月龄时开始乙肝疫苗免疫效果较好。Objective To investigate the appropriate age of infants born to single HBsAg positive mothers to vaccinate serum hepatitis vaccine. Methods 65 healthy infants born to single HBsAg positive mothers are divided into two groups to vaccinate serum hepatitis by the three-injection program at 0,1,6 months, The test group starts from 24 hours around the born moment, The control group from 3 months old. Detect the titre of anti-HBs by RIA 1,6,12,24 months after the last injection. Results The titre of anti-HBs of the infants in the test group is higher than the ones in the control group at 1,6,12,24 months after the last injection. Conclusion Serum hepatitis vaccine should be vaccinated at 3 mouths old in healthy infants born to HBsAg positive mothers.

关 键 词：肝炎疫苗 婴儿 免疫效果 

分 类 号：R186[医药卫生—流行病学]