辣素衍生物的合成及其对新月菱形藻生长的抑制活性  

Synthesis of Acrylamides Containing Capsaicin Derivative Moiety and Their Growth Inhibition Against Nitzschia Closterium

作　　者：徐焕志[1] 于良民[1] 李昌诚[1] 张志明[1] 

机构地区：[1]中国海洋大学海洋化学理论与工程技术教育部重点实验室青岛市海洋精细化工重点实验室,青岛266003

出　　处：《应用化学》2007年第8期911-916,共6页Chinese Journal of Applied Chemistry

基　　金：国家高技术研究发展计划(2003AA322060;2001AA623030等);新世纪优秀人才支持计划(NCET-04-0644);青岛市科技计划;山东省中青年科学家科研奖励基金资助项目

摘　　要：通过对辣素结构分析,设计合成了9种辣素衍生丙烯酰胺单体,分析了它们的产率和熔点。并通过FTIR、NMR测试技术进行了结构表征和确认。其中有7种化合物是新化合物。室内生物学实验初步证明,所合成的辣素衍生丙烯酰胺单体对新月菱形藻生长均显示一定的抑制活性,,其大小为HDMBA>DMBA≈BMA>TMBA≈HMTBA>CHBA>HMMBA>BHBA>HMBA。Nine uniquely functionalized antifouling acrylamide monomers derived from capsaicin were designed and synthesized. The yield of the reaction and the mp were respectively analyzed, and their stuctures were characterized by ^1 H NMR and FTIR. Seven of them including BMA, TMBA, HMTBA, HMMBA, CHBA, BHBA, HDMBA were synthesized for the first time. Growth inhibition assay result in the laboratory shows that those synthesized monomers possess an antifouling activity against Nitzschia closterium in the order of HDMBA 〉 DMBA ≈ BMA 〉 TMBA ≈HMTBA 〉 CHBA 〉 HMMBA 〉 BHBA 〉 HMBA.

关 键 词：辣素 合成 丙烯酰胺单体 防污 

分 类 号：O621.3[理学—有机化学]