热性惊厥患儿一氧化氮、一氧化氮合成酶及脑电图的临床分析  

Clinical analysis of nitric oxide,nitric oxide synthase and electroencephalograph in infants with febrile convulsion

作　　者：尹丽娟[1] 王开霞[1] 

机构地区：[1]华北煤炭医学院附属医院儿科,河北唐山063000

出　　处：《华北煤炭医学院学报》2007年第5期609-611,共3页Journal of North China Coal Medical College

摘　　要：①目的探讨热性惊厥患儿血清和脑脊液一氧化氮(NO)及其合成酶(NOS)的含量及其与热性惊厥发病机制和脑损伤的关系。②方法分别采用硝酸还原酶法、酶测定法测定患儿血清和脑脊液中NO、NOS的含量。应用定量数字视频脑电图仪检测脑电图。③结果热性惊厥组脑脊液中NO水平与NOS活性均明显低于对照组(P<0.05)。④结论热性惊厥发作可引起血清和脑脊液中NO水平明显低于对照组,提示NO可能参与抗惊厥机制及可能具有抗惊厥作用。Objective To investigate the levels of nitric oxide （NO） and nitric oxide synthase （ NOS ） of eerebrospinal fluid and serum in infants with febrile convulsion, and study the relation between febrile convulsion mechanism and brain injury. Methods The levels of NO and NOS in eerebrospinal fluid and serum were measured by nitric acid reduction enzyme method and enzyme measured method respectively. Results NO levels and NOS activity of eerebrospinal fluid in febrile convulsion group were singnificantly lower than those in control group（P 〈 0, 05 ）. Conclusion The level of NO in eerebrospinal fluid and serum was singnificantly lower than that in control group. No may participate in anti - convulsion mechanism and play a role in anti - convulsion.

关 键 词：惊厥 热性 一氧化氮 一氧化氮合成酶 

分 类 号：R725.9[医药卫生—儿科]