神经肽Y和神经元特异性烯醇化酶在小儿惊厥性疾病中的变化  

The changes and clinical significance of neuropeptide Y and neuron-specific enolase levels in children with convulsibility diseases

作　　者：周辉[1] 袁伯稳[2] 季风华[2] 朱余德[2] 赵建美[1] 张金莲[1] 

机构地区：[1]南通大学附属医院儿科,226001 [2]南通大学附属海安医院儿科

出　　处：《江苏医药》2007年第8期772-774,共3页Jiangsu Medical Journal

基　　金：南通市社会发展计划项目(S5853)

摘　　要：目的探讨神经肽Y(NPY)和神经元特异性烯醇化酶(NSE)在小儿惊厥性疾病中的水平变化及其临床意义。方法选择惊厥患儿62例,正常对照组20例。采用放射免疫法测定血浆NPY水平,酶联免疫法测定血清NSE水平。结果惊厥组(病毒性脑炎、癫痫和热性惊厥)惊厥发作后24h内血液NPY和NSE水平均显著高于正常对照组(P<0.01)。患儿惊厥发作后24h内血液NPY和NSE水平均显著高于正常对照组(P<0.01)。惊厥严重组患儿NSE水平显著高于普通组,而NPY水平显著低于普通组(P<0.01)。惊厥患儿急性期NPY与NSE呈负相关(r=-0.74,P<0.01)。结论小儿惊厥性疾病(病毒性脑炎、癫痫和热性惊厥)惊厥发作后可引起血液NPY和NSE水平的显著升高,其水平高低与脑损伤严重程度密切相关,可作为早期判断惊厥性脑损伤的客观指标。Objective To explore the changes and clinical significance of neuropeptide Y（NPY） and neuron-specific enolase（NSE） levels in children with convulsibility diseases. Methods Six-two children with convulsibility diseases were selected as convulsion group, and 20 healthy children served as normal control group. The blood samples were collected within the first 24 hours after seizure. The levels of NPY were measured by radioirnmunoassay, and the NSE detected by enzyme-linked immunosorbent assay. Results The levels of blood NPY and NSE in convulsion group （including viral encephalitis,epilepsy and febrile convulsion） were significantly higher than those in normal control group（P〈0.01）. The levels of NSE in children with serious convulsion group were significantly higher than those in common convulsion group（P〈0. 01） ,and the levels of NPY in serious convulsion group were significantly lower than those in common convulsion group（P〈0.01）. The level of NPY was negatively correlated with that of NSE in children with convulsion at acute stage （r=-0. 74, P〈0. 01）. Conclusion The levels of blood NPY and NSE in children with convulsibility diseases are significantly higher after seizure, which has a close correlation with the severity of brain injury and may serve as the objective indicators, in the early prediction of the degree of brain injury.

关 键 词：神经肽Y 神经元特异性烯醇化酶 惊厥 儿童 

分 类 号：R720[医药卫生—儿科]