240例乳腺癌组织中p53、C-erbB-2表达的临床分析  

Expression of p53 and C-erbB-2 in 240 cases with breast cancer tissue

作　　者：陆辉[1] 王水[1] 夏添松[1] 

机构地区：[1]南京医科大学第一附属医院普通外科,210029

出　　处：《江苏医药》2007年第8期790-791,F0002,共3页Jiangsu Medical Journal

基　　金：江苏省卫生厅重大科研资助项目(135-48)

摘　　要：目的探讨乳腺癌组织中p53、C-erbB-2表达及临床意义。方法对免疫组织化学染色SP法检测240例乳腺癌组织石腊切片上p53、C-erbB-2的表达结果进行回顾性分析。结果p53和C-erbB-2阳性表达率分别为53.3%和63.3%;阳性产物主要位于细胞核中,p53和C-erbB-2的表达与肿瘤组织分级、淋巴结转移呈显著相关(P<0.05),与PR、ER无显著相关。结论p53和C-erbB-2与乳腺癌的发生发展密切相关,可作为判断肿瘤浸润转移、指导治疗和估计预后的参考指标。特别是p53的表达水平及淋巴结转移是判断乳腺癌预后的独立有效指标。Objective To study the expression of p53 and C-erbB-2 in 240 cases with breast cancer. Methods The p53 and C-erbB-2 were detected with immunohistochemical stain method in 240 breast tissues. The relationship between p53 and C-erbB-2 and some clinicopathological factors were analyzed. Results The positive p53 and C-erbB-2 were mostly located in nucleus with the rates of 53.3% and 63.3%, respectively. The expression levels of p53 and C-erbB-2 were correlated possitively with histological grade （P〈0.05） and axillary lymph node metastases（P〈0. 05）, which were not with PR and ER status（P〉0.05）. Conclusions The p53 and C-erbB-2 play a role in the oncogenesis and development of breast cancer and their expression could be the useful indexes to assess the malignant level of breast carcinoma and its clinical prognosis. Expression of p53 and axillary lymph node metastases may be an independent prognostic indicator of operative survival in breast cancer patients.

关 键 词：P53 C-ERBB-2 乳腺癌 

分 类 号：R655[医药卫生—外科学]