噻氯吡啶与华法林治疗心腔内附壁血栓的临床对比研究  

CLINIC COMPARISON OF TREATMENT IN THROMBUS OF INTRACARDIAC MURAL THROMBUS WITH TICLOPIDINE AND WARFARIN

作　　者：宗立庚[1] 吴素华[1] 姜风琴[1] 吕钰[1] 贺树凤[1] 

机构地区：[1]山东省滨州市人民医院,256610

出　　处：《中国煤炭工业医学杂志》2007年第9期1016-1017,共2页Chinese Journal of Coal Industry Medicine

摘　　要：目的观察噻氯吡啶与华法林在治疗心腔内附壁血栓的疗效及安全性。方法将50例心腔内附壁血栓患者,随机分成二组,每组25例,分别给予噻氯吡啶与华法林治疗6个月,治疗前后分别行心脏彩超检查,对附壁血栓大小进行测定。结果噻氯吡啶组有效率为92.0%,华法林组为88.0%。二组比较,差异无统计学意义。结论噻氯吡啶、华法林在治疗心腔内附壁血栓中效果均满意,但应用噻氯吡啶不需监测凝血酶原时间、INR(国际标准比值),应用更安全。Objective To investigate the safety and efficiency of ticlopidine and warfarin on intracardiac mural thrombus. Methods 50 cases of patients with intracardiac mural thrombus were divided averagely into 2 groups. They were treated with ticlopidine and warfarin respectively for 6 months. Before and after the treatment, echocardiography both were underwent to mensurate the bulk of internal mural thrombus. Results The efficient ratio of ticlopidine group is 92.0% ,warfarin group is 88.0%. Comparing the two groups,there was no markable statistical difference. Conclusion Ticlopidine and warfarin are both in effect on intracardiac mural thrombus, but ticlopidine was more secure because it didn＇t have to inspect the time of prothrombin and INR（International Standard Ratio）.

关 键 词：心腔血栓 噻氯吡啶 华法林 心脏彩色超声 

分 类 号：R541[医药卫生—心血管疾病]