羊水胎粪污染新生儿脐血IgE水平测定及意义  

IgE level of cord blood in neonates with meconium-stained amniotic fluid

作　　者：宋飞[1] 周晓珊[1] 王陶[1] 金涛[1] 彭巧英[1] 

机构地区：[1]湖北省妇幼保健院新生儿科,湖北武汉430070

出　　处：《中国当代儿科杂志》2007年第4期361-363,共3页Chinese Journal of Contemporary Pediatrics

摘　　要：目的通过对羊水胎粪污染新生儿脐血IgE水平的检测,探讨羊水胎粪污染及其他高危因素对脐血IgE水平的影响。方法采用ELISA法测定脐血IgE的含量。结果①污染组新生儿脐血IgE水平与对照组比较有显著增高,两组间差异有非常显著性意义(t=4.03,P<0.01);②Ⅰ,Ⅱ,Ⅲ度羊水胎粪污染组分别与对照组比较,Ⅰ、Ⅲ度组差异有非常显著性意义(F=4.28,P<0.01);Ⅰ,Ⅱ,Ⅲ度组间两两比较差异无显著性;③将被检测的660例新生儿脐血IgE值按性别、胎龄、体重、胎次、早破水分组比较,早破水组与对照组比较差异有非常显著性;性别、胎龄、体重、胎次与对照组比较均差异无显著性。结论羊水胎粪污染新生儿脐血IgE水平显著增高,早破水也是脐血IgE水平显著增高的重要危险因素。对新生儿脐血IgE水平的观察,可作为婴幼儿期过敏性疾病发生的预测的因素之一。Objective To study the effects of meconium-stained amniotic fluid on the cord blood IgE level in neonates. Methods A total of 404 neonates with meconium-stained amniotic fluid who were born by cesarean delivery between August 2003 and August 2005 （meconium-stained group） and 256 neonates with normal amniotic fluid delivered by cesarean （control group） were enrolled in this study. The meconium-stained group consisted of 80 cases of mild, 62 cases of moderate and 262 cases of severe meconium-stained amniofic fluid. The cord blood IgE level was measured using ELISA. Results The cord blood IgE level in the meconium-stained group was statistically higher than that in the control group （t = 4.03, P 〈 0.01 ）. There were significant differences between the mild and severe meconium-stained subgroups and the control group for the cord blood IgE level （ F = 4.28, P 〈 0.01 ）. The cord blood IgE level in neonates with premature rupture of the membrane between the meconium-stained and the control groups was statistically different. Sexes, gestational age, birth weight and birth order were not associated with the IgE level of cord blood. Conclusions The cord blood IgE levels in neonates with meconium-stained amniotic fluid increase. Premature rupture of the membranes may be associated with an increase of cord blood IgE level.

关 键 词：羊水 胎粪 脐血 IGE 新生儿 

分 类 号：R722.1[医药卫生—儿科]