血液透析患者颈动脉粥样硬化的危险因素分析  

The risk factors of hemodialysis in patients with carotid atherosclerosis

作　　者：曹礼应[1] 余月明[1] 郭虹[1] 余开慧[1] 肖丽佳[1] 段建[1] 

机构地区：[1]成都军区昆明总医院肾内科,云南昆明650032

出　　处：《中国医师杂志》2007年第7期871-872,共2页Journal of Chinese Physician

摘　　要：目的 探讨维持性血液透析（HD）患者颈动脉粥样硬化（AS）的危险因素。方法 检测132例HD患者一般临床指标，同时应用高分辨彩色B超测患者颈动脉内膜-中层厚度（IMT）及粥样硬化斑块，分析HD患者AS的危险因素。结果 粥样硬化斑块阳性的HD患者年龄、病程、HD时间、胆固醇（TCH）、低密度脂蛋白（LDL）、C-反应蛋白（CRP）显著高于阴性患者，而阳性患者血白蛋白（Alb）、标准化蛋白分解率（nPCR）显著低于阴性患者。AS的危险因素为：nPCR、HD时间、CRP、LDL、高血压。结论 HD并AS的患者病程及HD时间长，TCH、LDL、CRP显著增高，血Alb、nPCR低下，HD患者AS的危险因素为nPCR、HD时间、CRP、LDL、高血压。Objective To investigate the risk factors of hemodialysis （HD） patients with carotid atherosclerosis （AS）. Methods Clinical index was measured, and intima - media thickness （IMT） of extraeranial common carotid artery and presence of atherosclerotic plaques were determined by high - resolution B - mode ultrasonography. And the risk factors of HD patients with carotid AS were investigated. Results The age, disease duration, HD duration, total cholesterol（TCH） , low density lipoprotein （LDL） , serum C - reactive protein （CRP） in HD with atherosclerotic plaque were significantly higher than those in HD patients without atherosclerotic plaque patients, but the serum albumin （Alb） and normalized protein catabolic rate （nPCR） were significantly lower, The risk factors of HD patients with AS were nPCR, HD duration, CRP, LDL and hypertension. Conclusion The HD patients with AS had a long disease duration. TCH, LDL, CRP in HD with atherosclerotic plaque were increased, and Alb, nPCR were decreased. The risk factors of HD patients with AS were nPCR, HD duration, CRP, LDL and hypertension,

关 键 词：肾透析 动脉硬化 危险因素 

分 类 号：R54[医药卫生—心血管疾病] R692[医药卫生—内科学]