早发2型糖尿病的临床特点  

A study on clinical characteristics of early - onset type 2 diabetes mellitus

作　　者：周少玲[1] 史虹莉[2] 

机构地区：[1]青岛大学医学院附属烟台毓璜顶医院内分泌科,山东烟台264000 [2]复旦大学附属华山医院内分泌科

出　　处：《中国医师杂志》2007年第7期883-885,共3页Journal of Chinese Physician

摘　　要：目的 研究早发2型糖尿病（T2DM）患者的临床特点。方法 将305例分为早发T2DM（EOD组120例）、晚发T2DM（LOD组185例）和年轻非糖尿病对照组（YN组25例）3组，探讨EOD组在血压、BMI、腰围、WHR、FPG、FINS、FC—P、HbA1c、血脂、HOMAIR、HOMAIS等方面的特点。结果 和LOD组相比，EOD组糖尿病家族史阳性率较高（P〈0.01），和YN组相比，EOD组腰围、WHR、TG、LDL、FINS、HOMAIR、HbA1c、FPG水平较高；和LOD相比，EOD组FPG、HbA1C、TG、HOMAIR水平较高；二分类Logistic逐步回归分析发现糖尿病家族史、高WHR、高TG、高FINS和低HDL可能是早发糖尿病发生的危险因素。结论 尽早识别糖尿病家族史、高WHR、高TG、高FINS和低HDL等危险因素，对于早发T2DM的早期预防具有重要的意义；同时在早发T2DM的治疗过程中要注意控制血糖、纠正血脂紊乱，保护胰岛β细胞功能。Objective In this study, we describe the clinical characteristics in early onset diabetes mellitus. Methods 305 cases were divided into three groups, EOD group （ early onset diabetes mellitus, 18 〈 EOD ≤40 years old）, YN group （ young, healthy, non - diabetic individuals, 18 〈 YN≤40 years old） and LOD group （late onset diabetes mellitus, 40 〈 LOD years old）. A cross -sectional study was carried out to analyze the clinical characteristics, including body mass index （BMI） , waist circumstance, waist to hip ratio （WHR）, fasting plasma glucose level （FPG）, fasting insulin level （FINS）, fasing C peptide （FC -P）, HbAlc, serum lipid profiles. Insulin resistance （IR） and beta cell function were assessed by HOMAIR index and HOMAIS index respectively. Binary logistic regression analysis was used to identify the risk factors for EOD individuals. Results EOD group had significantly higher rate of T2DM history compared with LOD group （30. 8% vs 18. 4%, P 〈0. 01 ）. The mean values of waist circumstance, WHR, TG, LDL, FINS, FPG, HbA1C, and HOMAIR in EOD group were significantly higher than that in YN group. The levels of FPG, HbA1C, TG, and HOMAIR in EOD group were higher than that in LOD group. Conclusion High FINS, high WHR, hypertriglyceridaemia, low HDL and family history of T2DM may be risk factors for EOD. Early identification of these risk factors may be useful for primary prevention of EOD. It must be adopted early to strict control blood glucose and lipid profile and protect the residual pancreatic beta cell.

关 键 词：糖尿病 2型 

分 类 号：R587[医药卫生—内分泌]