流体剪切应力诱导内皮细胞迁移的力学-化学信号途径  

Mechano-chemical Signal Pathway of Endothelial Cells Migration Induced by Fluid Shear Stress

作　　者：余昶[1] 张怡[1] 刘肖珩[1] 

机构地区：[1]四川大学华西医学中心生物医学工程研究室,四川成都610041

出　　处：《航天医学与医学工程》2007年第4期308-312,共5页Space Medicine & Medical Engineering

基　　金：国家自然科学基金资助项目(30570450);四川省青年科技基金资助项目(062Q026-009)

摘　　要：内皮细胞在流体剪切应力作用下进行迁移运动,与机体多种生理病理过程密切相关,也是近年来国内外研究的热点问题。在力学刺激作用下,内皮细胞发生形态学改变、表面受体重新分布,引起一系列化学变化和信号传导。这些级联反应引起细胞形态学上的进一步变化,如极化、突起、黏附,最终导致细胞的迁移运动。本文综述了流体剪切应力作用下内皮细胞迁移的形态模型及力学分析,将有助于深入了解流体剪切应力诱导内皮细胞迁移的力学-化学耦合信号传导途径的内在机理。The migration of endothelial cell induced by fluid shear stress is related to many physiological and pathological responses in organism. The redistribution of membrane receptors and proteins, caused by shear stress, is a vital step for cell migration, followed by chemical reactions and signal transduction. Then cell morphological changes are induced, such as polarity, protrusion, and adhesion, which lead to the migration of endothelial cell at last. The goal of this paper is to review what is known about the mechanical models of endothelial cell migration and the responses of cells to fluid flow. It is helpful for better understanding the intrinsic mechanism of mechano-chemical signal pathway of the migration of endothelial cells induced by fluid shear stress.

关 键 词：流体剪切应力 内皮细胞 细胞迁移 力学感受器 

分 类 号：R318.01[医药卫生—生物医学工程]