补阳还五汤加减治疗冠心病对血脂和雌二醇代谢的影响  

Change of Serum Lipid and Estradiol with Buyanghuanwu Decoction to Treat Coronary Heart Disease

作　　者：黄宪章[1] 金卓祥[2] 任燕歌[1] 丁海明[1] 林莉[1] 庄俊华[1] 

机构地区：[1]广东省中医院二沙岛分院检验科,广州510105 [2]广东省中医院二沙岛分院心脏专科,广州510105

出　　处：《微循环学杂志》2007年第3期29-30,共2页Chinese Journal of Microcirculation

基　　金：广东省社会发展攻关课题(粤科社字[2002]254号)资助

摘　　要：目的:探讨补阳还五汤加减治疗冠心病血脂和雌二醇(E2)代谢的变化。方法:49例冠心病患者服用补阳还五汤加减治疗两个月,应用酶法检测治疗前后的总胆固醇(TC)、甘油三脂(TG),均相酶法检测高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),免疫透射比浊法检测载脂蛋白A1(ApoA1)和载脂蛋白B(ApoB),化学发光免疫法检测雌二醇(E2)。结果:治疗后TC、LDL-C、ApoB降低,ApoA1升高,与治疗前比较差异有显著性意义(P<0.05),TG、HDL-C、E2治疗前后比较无统计学差异(P>0.05)。结论:补阳还五汤加减治疗冠心病有助于改善血脂代谢。Objective:To explore change of serum lipid and estradiol(E2)with Buyanghuanwu Decoction to treat coronary heart disease.Method:49 coronary heart disease patients were treated 2 months by Buyanghuanwu Decoction.Total cholesterol(TC)and triglycerides(TG)were measured by enzyme method before and after treatment.High density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)were measured by homogeneous phase.Apolipoprotein A1(ApoA1)and apolipoprotein B(ApoB)were measured by immune turbidimetry.E2 was measured by chemiluminometric immunoassay.Results:Post-treatment level of TC,LDL-C and ApoB was decreased,that of ApoA1 was increased,there were statistically significant(P<0.05)results before and after treatment such as TC,LDL-C,ApoA1 and ApoB.There were no statistically significant(P>0.05)such as TG,HDL-C and E2.Conclusion:It is helpful to improve serum lipid metabolic level by Buyanghuanwu Decoction to treat coronary heart diseases.

关 键 词：补阳还五汤 加减治疗 冠心病 冠状动脉粥样硬化性心脏病 血脂 醇代谢 人类健康 活血化瘀 

分 类 号：R289.5[医药卫生—方剂学]