氟代β-二酮化合物的合成及结构表征  

Synthesis and characterization of two new β-diketones containing trifluoromethyl group

作　　者：范玲[1] 郑春阳[2] 汪敦佳[2] 

机构地区：[1]华中师范大学化学学院,湖北武汉430079 [2]湖北师范学院生化分析技术湖北省重点实验室,湖北黄石435002

出　　处：《化学试剂》2007年第8期452-454,476,共4页Chemical Reagents

基　　金：湖北省教育厅科研基金资助项目(J20052002)

摘　　要：芳香酮和三氟乙酸乙酯在强碱CH3ONa作用下发生经典Claisen缩合反应,合成了两种未见文献报道的含氟β-二酮:4,4,4-三氟-1-(6-甲氧基-2-萘基)-1,3-二酮和4,4,4-三氟-1-(4-苄氧基苯基)-1,3-二酮。两种氟代β-二酮在氯仿溶液中几乎完全以烯醇式存在,其结构通过红外光谱、核磁氢谱、质谱和元素分析进行了确证。Two new β-diketones containing trifluoromethyl groups, 4,4,4-trifluoro-1-（ 6-methoxynaphthalen-2-yl ） butane-1, 3-dione and 4,4,4-trifluoro-1-（ 4-phenylmethoxyphenyl ） butane-1,3-dione were synthesized from aromatic ketones and ethyl tri-fluoracetate by the classical Claisen condensation reaction using CH3ONa as the strong base. Their structures were determined by means of IR, 1^ HNMR, MS spectra and elemental analysis. The resuits showed that the two β-diketones containing the trifluoromethyl group almost completely exist in the enol form in the chloroform solvent.

关 键 词：Β-二酮 三氟甲基 合成 Claisen缩合 

分 类 号：O625.43[理学—有机化学]