2005年临床分离病原菌的分布及耐药性分析  

Analysis of distribution and resistance of pathogen isolated from clinical specimens in 2005

作　　者：林素珍[1] 赖善城[1] 林燕青[1] 罗腾火[1] 

机构地区：[1]福建省龙岩市第二医院,福建龙岩364000

出　　处：《药学实践杂志》2007年第4期229-231,共3页Journal of Pharmaceutical Practice

摘　　要：目的:调查我院临床分离病原菌的分布及耐药状况,为临床用药提供依据。方法:对我院2005年1～12月分离的病原菌作回顾性分析。结果:共检出1572株致病菌,其中革兰阳性菌599株,占38.1%,革兰阴性菌478株,占30.4%,真菌494株,占31.4%。药敏结果:敏感率最高的前三位抗菌素是:万古霉素95.8%、亚胺培南88.2%、头孢吡肟83.6%,而耐药率最高的分别为:克拉霉素79.3%、克林霉素74.0%、红霉素73.5%。结论:临床真菌感染逐年上升;检出革兰阳性菌比例较高且耐药率高;酶抑制剂能明显降低革兰阴性菌的耐药率,但不能明显降低革兰阳性菌的耐药率。应加强抗菌素的临床合理使用。Objective： To investigate the actualities of the distribution and resistance of pathogen isolated from clinical specimens , to provide the basis for clinical rational use drug. Methods：The pathogenes isolated from clinical specimens in 2005 were analysed. Resuits：It was 1 572 pathogenes isolated from clinical specimens which were sent to be examined. Gram positive bacteria was 599, 38.1 percent ; Gram negative bacteria was 478, 30.4 percent; Fungi was 494,31.4 percent ; The result of drug sensitive test indicated： the highest sensitive antibiotic ： vancomycin 95.8 percent,imipenem 88.2 percent, cefepime 83.6 percent. The highest resistance antibiotic： clarithromycin 79.3percent, clindamycin 74.0 percent, erythromycin 73.5 percent. Conclusion ： The Fungi infected rate is increasing, the rate of Gram positive bacteria and its resistance were high; the enzme-inhibited can reduce the resistance rate of Gram negative bacteria, not reduce the resistance rate of Gram positive bacteria. It would be strengthed the antibiotic rational use in clinic.

关 键 词：病原菌 抗菌素 耐药分析 

分 类 号：R37[医药卫生—病原生物学]