老年期抑郁症患者血清瘦素水平变化及其临床意义  

Clinical significance of serum leptin level in senile depressive patients

作　　者：梅刚[1] 袁勇贵[1] 李海林[1] 方群[2] 

机构地区：[1]南京医科大学脑科医院精神科,南京210029 [2]南京医科大学脑科医院研究所,南京210029

出　　处：《中国行为医学科学》2007年第8期702-704,共3页Chinese Journal of Behavioral Medical Science

基　　金：南京市医学科技发展项目资金资助（YKK0351）

摘　　要：目的探讨老年期抑郁症与血清瘦素水平的关系。方法采用放射免疫法对57例老年期抑郁症患者和35例正常老年人的血清瘦素浓度进行测定。结果老年期不伴Ⅱ型糖尿病抑郁症患者组的血清瘦素水平[（25．13±21．29）ng／ml]和伴Ⅱ型糖尿病抑郁症患者组的血清瘦素水平[（41．65±28．19）ng／ml]均显著高于正常老年人[（10．84±9．16）ng／ml]（P〈0．01），老年期伴Ⅱ型糖尿病抑郁症患者组的血清瘦素水平显著高于不伴Ⅱ型糖尿病抑郁症患者组（P〈0．05]。18例老年期不伴Ⅱ型糖尿病抑郁症患者治疗前后血清瘦素水平[（24．13±24．55）ng／ml、（28．84±36．56）ng／ml]差异无显著性（P=0．497）；老年期抑郁症患者的HAMD评分与血清瘦素水平无显著相关性（r=-0．071，P=0．633）。结论老年期抑郁症存在瘦素分泌异常增高，可能与抑郁症状有关；五羟色胺再摄取抑制剂不影响血清瘦素水平；糖代谢异常影响瘦素分泌。Objective To explore the relationship between the serum leptin level and senile depression. Methods The serum leptin level was determined by radioimmunoassay in 57 senile depressive patients and 35 healthy controls. Results Before treatment, compared with the control, the serum leptin level was significantly higher in senile depressive group both with and without type Ⅱ diabetes mellitus. The serum leptin ,level of senile depressive group with type Ⅱ diabetes mellitus was significantly higher than the group without type Ⅱ diabetes mellitus. After the treatment,the change of the serum leptin showed no significant difference in 18 depressive patients without type Ⅱ diabetes leptin. The serum leptin level had no significant correlations with the total scores of Hamilton Depression Scale in depressive patients. Conclusion The serum leptin levels in senile depression was significantly elevated, may has a correlation with depression symptoms. SSRI doesn＇ t change the serum leptin level. Abnormal glucose metabolism has an effect on leptin secretion.

关 键 词：老年期抑郁症 瘦素 糖尿病 

分 类 号：R686[医药卫生—骨科学]