超短波治疗庆大霉素所致急性肾损害大鼠的实验研究  

An experimental study of the protective effects of the ultrashort wave diathermy on gentamycin-induced acute renal iujury

作　　者：李香云[1] 黄兆民[1] 张长杰[1] 张石飞[1] 

机构地区：[1]中南大学湘雅二医院康复医学科,长沙410011

出　　处：《中华物理医学与康复杂志》2007年第7期433-435,共3页Chinese Journal of Physical Medicine and Rehabilitation

摘　　要：目的探讨超短波对庆大霉素造成的大鼠急性肾功能损害的治疗作用。方法将18只Sprague-Dawley大鼠随机分为正常组、造模组和治疗组,每组6只。治疗组应用超短波治疗,每日1次,10次为1个疗程,共治疗2个疗程。观察大鼠肾组织病理变化,检测大鼠尿液中N-乙酰-β-D-氨基葡萄苷酶(NAG)、尿视黄醇结合蛋白(RBP)、α_1-微球蛋白(α_1-MG)、β_2-微球蛋(β_2-MG)含量,以及血肌酐(SCr)和血尿素氮(BUN)含量。结果治疗组大鼠肾组织病理损害轻微,仅见肾小管上皮轻度浊肿;大鼠尿NAG、RBP、α_1- MG和β_2-MG以及血SCr和BUN含量均较造模组低,差异有统计学意义(P<0.05),与正常组比较,除尿RBP和血SCr外,差异均无统计学意义(P>0.05)。结论超短波治疗对庆大霉素造成的大鼠急性肾功能损害有一定的治疗作用。Objective To observe the treatment effects of the ultrashort wave diathermy on gentamycin-induced acute renal injury of rats. Methods Eighteen Sgrague-Dawley rats were randomly divided into a normal group （6 rats）, a model group （6 rats） and a treatment group （6 rats）, the treatment group was treated with ultra- short wave diathermy once a day for a total of 20 days. The observed indexes were NAG, RBP, α1-MG, β2-MG in the urine of rats; the SCr, BUN in the blood of rats were also tested and the pathological changes of the renal observed. Results The pathological injuries of those in the ultrashort wave treatment group was slighter than the con- trol group; the NAG, RBP, α1-MG, β2-MG in the urine and the SCr, BUN in the blood of treatment group were lower than those of the model group （P 〈 0.05）. Conclusion The ultrashort wave diathermy is of therapeutic value in the treatment of gentamycin-induced acute renal injury in rats.

关 键 词：庆大霉素 急性肾损害 肾衰竭 超短波 

分 类 号：R454[医药卫生—治疗学]