仔猪大肠杆菌病三价蜂胶灭活疫苗猪体血清抗体消长规律  

Rising and Falling Rule of Serum Antibodies in Pigs Vaccinated with E. Coli Trivalent Inactivated Vaccine in Propolis-adjuvant for Newborn Piglets

作　　者：范忠军 柴虹 朱万光 李士成 

机构地区：[1]山东滨州华宏生物制品有限责任公司研究所,山东滨州256600

出　　处：《吉林畜牧兽医》2007年第8期11-12,15,共3页Jilin Animal Husbandry and Veterinary Medicine

摘　　要：采用大肠杆菌C83549(O149:K88ac)、C83644(O68:K99)、C83710(O9:987P)菌株制备抗原,以蜂胶为佐剂,研制仔猪大肠杆菌病三价蜂胶灭活疫苗,疫苗成品检验均符合相关要求。将疫苗免疫妊娠母猪并用凝集试验测定其所产仔猪的抗体消长规律,并研究疫苗免疫保护相关性。结果表明:妊娠母猪产前40d和15d各免疫1次所产仔猪母源抗体效价较高,仔猪在整个哺乳期都可以得到保护。同时也可运用产前30d和10d进行免疫接种方法。E. Coli trivalent inactivated vaccine for newborn piglets was developed using C83549 （O149： K88ac）, C83644 （068： K99）, C83710 （09： 987P） bacterium strains as its antigen and in propolis-adjuvant. After a series of detecting tests, five batches of the vaccine produced in lab were proved harmless and potent. Agglutination test was applied to examing antibody level of the piglets. The results showed that maternal antibody titer of suckling pigs produced by sow vaccinated two times was higher, and the piglets can be protected from E.coli attacking during nursing period.

关 键 词：大肠杆菌 蜂胶疫苗 妊娠母猪 消长规律 

分 类 号：S852.5[农业科学—基础兽医学]