侧链脂肪酸 BMIPP 的 ^(125)I 标记和动物体内分布  

125 I radioiodination of BMIPP and its distribution in animals

作　　者：钟高仁[1] 陈绍亮[1] 许兰文[1] 修雁[1] 孙晓光[1] 陈可靖[1] 赵惠扬 朱桐 

机构地区：[1]上海医科大学

出　　处：《核技术》1997年第5期277-280,共4页Nuclear Techniques

基　　金：国家教委博士点基金;卫生部科研基金

摘　　要：在乙醇和水的混合溶液中，通过新生态Ｃｕ（Ｉ）催化碘同位素交换反应制得１２５Ｉ－ＢＭＩＰＰ，经乙醚提取纯化后，其放射化学纯度＞９５％，制备过程中总放射性得率＞４０％。小白鼠体内分布显示２％左右的注射剂量存在于心肌组织，且长时间保持稳定。I-BMIPP was prepared by isotopic exchange using Cu(Ⅰ) as catalyst in an ethanal water mixture. The radiochemical purity of 125 I-BMIPP was >95%, and the overall radioactivity yield was >40%. In rat, the myocardum kept about 2% of injection dose and stabilized in 3 h. It indicated that BMIPP is a suitable agent for myocardial fatty acid metabolism imaging.

关 键 词：心肌代谢显像 侧链脂肪酸 碘125 同位素标记 

分 类 号：R817.1[医药卫生—影像医学与核医学]