^(134)Cs 的骨吸收剂量诱发骨髓 PCE 微核率及其持续作用  

Micronucleus formation and its sustained action in bone marrow cells induced by absorption dose of 134 Cs in skeleton

作　　者：朱寿彭[1] 夏芬[1] 杨卫东[1] 

机构地区：[1]苏州医学院

出　　处：《核技术》1997年第5期288-291,共4页Nuclear Techniques

基　　金：国家自然科学基金

摘　　要：研究了机体内污染１３４Ｃｓ在小鼠骨骼中的滞留过程和吸收剂量诱发骨髓嗜多染红细胞（ＰＣＥ）微核率的量效关系及其持续作用特性。由１３４Ｃｓ在骨骼中滞留动态拟合方程导出其半滞留期为５．７３天；１３４Ｃｓ诱发骨髓ＰＣＥ的微核形成率随机体摄入１３４Ｃｓ放射性活度的增加而升高，且在骨髓ＰＣＥ微核形成率（Ｙ，％）与摄入１３４Ｃｓ放射性活度（Ｘ，ｋＢｑ／ｇ）之间呈现幂函数关系（Ｙ＝０．２４６Ｘ０．３０７）；由于１３４Ｃｓ内照射的作用持续性，其诱发的骨髓ＰＣＥ微核率在连续４７天的观察中仍持续增升。In this paper sustained effect of micronucleus formation in bone marrow cells induced by absorption dose of 134 Cs in skeleton was studied. The results indicated that a fitted equation to describe the retention of 134 Cs in bone marrow cells is obtained as follows: R(t)=0.0029e -0.121t . Where the T 1/2 in skeleton is 5.73d. Experimental results showed that obvious increase of micronucleus formation could be induced by 134 Cs with a threshold dose as 0.93kBq/g. The relations between injected dose(X, kBq/g) and micronucleus formation rates(Y, %) can be expressed by an power function Y=0.246X 0.307 . In accordance with the peculiarity of internal exposure with 134 Cs, sustained effect of micronucleus formation in bone marrow cells may continued to 47 days.

关 键 词：骨骼 吸收剂量 微核 PCE 铯134 放射病理 

分 类 号：R818.02[医药卫生—放射医学]