4种抗生素治疗细菌性上呼吸道感染的成本-效果分析  

Four Antibiotics in the Treatment of Upper Respiratory Tract Bacterial Infection: Cost- Effectiveness Analysis

作　　者：王启平[1] 黄立相[1] 

机构地区：[1]广州医学院附属深圳沙井医院,深圳市沙井人民医院,深圳市518104

出　　处：《中国药房》2007年第23期1771-1773,共3页China Pharmacy

摘　　要：目的:评价治疗细菌性上呼吸道感染的4种抗生素药物的成本-效果。方法:将102例细菌性上呼吸道感染患者随机分为G1、G2、G3、G4组,分别给予琥乙红霉素分散片、罗红霉素胶囊、阿奇霉素分散片、克林霉素分散片治疗,疗程分别为10、10、5、10d,运用药物经济学方法进行成本-效果分析。结果:G1、G2、G3、G4组的成本分别为143.20、114.00、69.55、323.20元;有效率分别为88.89%、91.67%、91.30%、92.86%(P>0.05);成本-效果比分别为161.10、124.36、76.18、348.05;G1、G2、G4组相对于G3组增量成本-效果比分别为—3056.02、12013.51、16259.62,G1、G2、G4组的成本-效果比显著高于G3组(P<0.05)。结论:阿奇霉素分散片治疗方案较好。OBJECTIVE： To evaluate the cost- effectiveness of four antibiotics in the treatment of bacterial upper respiratory tract infection.METHODS： A total of 102 patients with bacterial upper respiratory tract infection were randomly assigned to receive Erythromycin ethylsuccinate dispersible tablets for 10 days（Group 1）, roxithromycin capsules for 10 days （Group 2）, azithromycin dispersible tablets for 5 days（Group 3） or klindamycin dispersible tablets for 10 days（Group 4） .The cost- effectiveness analysis was performed with pharmacoeconomic method.RESULTS：The costs of Groups 1,2,3 and 4 were 143.20 yuan, 114.00 yuan, 69.55 yuan and 323.20 yuan, respectively; the effective rates were 88.89%, 91.67%, 91.30% and 92.86%, respectively（P 〉 0.05）; and the cost- effectiveness ratios were 161.10,124.36, 76.18 and 348.05, respectively .The incremental cost- effectiveness ratios of Groups 1, 2 and 4 were -3 056.02, 12 013.51 and 16 259.62 respectively as compared with Group 3.The cost - effectiveness ratios of Groups 1,2 and 4 were significantly higher as against Group 3（P 〈 0.05）.CONCLUSION：Azithromycin dispersible tablet is the best one among the 4 groups.

关 键 词：细菌性上呼吸道感染 琥乙红霉素 罗红霉素 阿奇霉素 克林霉素 

分 类 号：R956[医药卫生—药学] R978.1