甲基黄酮醇胺在家兔体内的代谢动力学  

Pharmacokinetics of methylflavonolamine in rabbits

作　　者：员克明[1,2,3] 张明升[1,2,3] 孟青枝 

机构地区：[1]山西医科大学法医学系 [2]山西医科大学药理学教研室 [3]山西省平陆县人民医院内科

出　　处：《山西医科大学学报》1997年第1期20-21,共2页Journal of Shanxi Medical University

摘　　要：建立了兔血清中甲基黄酮醇胺的高效薄层荧光扫描检测方法，血清中甲基黄酮醇胺的线性检测范围为０．１～４ｍｇ／Ｌ，最低检出浓度为０．０４ｍｇ／Ｌ；研究了甲基黄酮醇胺在家兔体内的代谢动力学，甲基黄酮醇胺在家兔体内的代谢动力学符合二室开放模型，分布相半衰期为０．２６±０．１１ｈ，消除相半衰期为４．０９±１．２０ｈ。A HPTLC fluorence scanning method of methylflavonolamine in rabbits was developed.The extraction calibration curve of methylflavonolamine in rabbit serum was liner over the range of 0 1 mg/L to 4 mg/L,the limit of detection was 0 04 mg/L.This method was further used in the pharmacokinetic studies on methylflavonolamine in rabbits.A series of pharmacokinetic parameters were obtained.The results show that the kinetics of methylflavonolamine in rabbits fits well to a two compartment open model. T1/2 of distribution phase and elimination phase are 0 26±0 11 h and 4 09±1 20 h.

关 键 词：甲基黄酮醇胺 色谱法 光谱测定法 药代动力学 

分 类 号：R973[医药卫生—药品] R969.1[医药卫生—药学]