中枢去甲肾上腺素通路和前列腺素参与IL-6、TNFα对大鼠下丘脑室旁核神经元的兴奋作用  

CENTRAL NORADRENERGIC PATHWAY AND PROSTAGLANDIN ARE INVOLVED IN THE IL 6 AND TNFα INDUCED EXCITATION OF NEURONS IN THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS OF RAT

作　　者：杨宏[1] 王浩军[1] 邱建勇[1] 黄传书[1] 鞠躬[1] 

机构地区：[1]第四军医大学神经科学研究所

出　　处：《动物学报》1997年第2期151-156,共6页ACTA ZOOLOGICA SINICA

摘　　要：应用免疫组织化学方法研究了６羟多巴胺化学性损毁中枢去甲肾上腺素通路和中枢引入前列腺素合成抑制剂消炎痛对脑室注射白细胞介素６、肿瘤坏死因子α诱导下丘脑室旁核小细胞Ｆｏｓ表达的影响。结果显示，这两种处理均可使Ｆｏｓ表达细胞数目明显减少，说明白细胞介素６、肿瘤坏死因子诱导室旁核小细胞神经元Ｆｏｓ表达的作用与中枢去甲肾上腺素通路和中枢前列腺素有关。By immunohistochemical (IHC) method, the present study investigated the influence of neurotoxin 6 hydroxydopamine (6 OHDA) and indomethacin, an inhibitor of prostaglandin synthesis, on the Fos expression of parvocellular neurons of paraventricular nucleus (PVN) induced by centrally administration of interleukin 6 (IL 6) and tumor necrosis factorα (TNFα). The result showed that the numbers of Fos expression neurons were significantly reduced by the two kinds of treatments. The result suggests that central noradrenergic pathway and prostaglandin are involved in the IL 6 and TNF induced excitation of parvocellular neurons of PVN.

关 键 词：神经元 兴奋 下丘脑 白细胞介素6 肿瘤坏死因子 

分 类 号：R338.11[医药卫生—人体生理学]