高效液相法测定复方胃克宁胶囊中呋喃唑酮和强力霉素的含量  

DETERMINATION OF THE CONTENT OF FURAZOLIDONE AND DOXY CYCLINE IN COMPOUND WEIKENING CAPSULES BY HPLC

作　　者：苗术[1] 李涛[1] 邱丽萍[1] 李清琦 焦文才[1] 尹继业[2] 周贵林 尚彦城[4] 张尔力 齐宝奎[4] 苗翠萍 

机构地区：[1]齐齐哈尔医学院药理学教研室 [2]齐齐哈尔市第一医院药剂科 [3]拜泉县卫校 [4]齐齐哈尔医学院第一附属医院药剂科

出　　处：《齐齐哈尔医学院学报》1997年第1期7-9,共3页Journal of Qiqihar Medical University

摘　　要：采用高效液相法测定复方胃克宁中呋喃唑酮和强力霉素的含量,以外标法峰面积定量、采用YWG,C_(18)色谱柱;流动相为甲醇-0.025mol/L磷酸二氢纳-三乙胺(38∶62∶0.03)的0.025％十二烷基磺酸钠溶液(磷酸调pH3.0),检测波长259nm。结果表明,呋喃唑酮和强力霉素的平均回收率分别为100.2％(RSD=0.38)和99.6％(RSD=0.46);本法操作简单,结果准确,灵敏度高,可作为复方胃克宁常规分析的手段。The determination of the content of furazolidone and doxycycine in co_ mpound Weikening capsules by HPLC were quan titated by peak area exter nal standard method.Analytical column packed with YWG, C18 was used.The mobil phase consisted of 0.025% sodium laurylsulfonate liqiud of methanol, 0.025%mol/L sodium dihydrogen phosphate and triethylanmine (38:62:0.04 pH3.0).The 259 nm wavelength detector was selected.The average recoveries of furazolidone and doxycline were 100.2%(RSD=0.38), 99.6% (RSD=0.46) respectively. The character of our method is simple, accurate and high sen sitive.It can. be used in compoud weikening capsules common analysis.

关 键 词：高效液相色谱法 复方胃克宁胶囊 呋喃唑酮 强力霉素 

分 类 号：R975[医药卫生—药品] R927.2[医药卫生—药学]