缬沙坦对实验性兔动脉粥样硬化斑块形成的影响  

The effect of valsartan in experimental atherosclerotic rabbits

作　　者：曾永利[1] 成蓓[1] 马志强[2] 

机构地区：[1]华中科技大学同济医学院附属协和医院老年科,武汉430022 [2]中国人民解放军第一六一中心医院心内科

出　　处：《华中医学杂志》2007年第4期296-298,共3页Central China Medical Journal

摘　　要：目的研究缬沙坦对实验性兔动脉粥样硬化血管壁过氧化物酶体增殖物激活受体γ(PPARγ)和单核细胞趋化蛋白-1(MCP-1)的影响。方法24只新西兰白兔随机分为3组:正常对照组、动脉粥样硬化(AS)造模组、缬沙坦干预组,喂养12周。进行血脂测定、主动脉内膜/中膜比值测定,采用RT-PCR检测PPARγ和MCP-1mRNA的表达。结果缬沙坦组血管壁PPARγmRNA的表达较AS组明显增加(P<0.05),缬沙坦组血管壁MCP-1mRNA的表达较AS组明显减少(P<0.05)。血清胆固醇、甘油三酯、低密度脂蛋白胆固醇缬沙坦组与AS组比较均无显著性差异(P>0.05),但均高于对照组(P<0.01)。缬沙坦组内膜/中膜厚度比值较AS组明显减小(P<0.05)。结论缬沙坦能够抑制血管壁细胞MCP-1的表达,其具有抗炎作用,抗炎作用可能与其改善PPARγ表达有关。Objective To study the effect of valsartan on the expression of peroxisome proliferators-activated receptor gamma （PPARγ） and monocyte chemoattractant protein-1 （MCP-1） in experimental atherosclerotic rabbits. Methods Twenty four male Newzland rabbits were randomly divided into 3 group： group l：normal rabbit chow; group 2：cholesterol diet; group 3：cholesterol diet supplemented by valsartan. All rabbits were fed according to experiment design for 12 weeks. Blood samples were abstracted from vein for detection of serum lipid. The intima-media thickness were measured. PPARγ and MCP-1 were examined by reverse transcription polymerase chain reaction. Results The expression of PPAR7 was higher in group 3 than group 2 （P〈0. 05）. The expression of MCP-1 was higher in group 2 than group 3 （P〈0. 05）. Levels of serum TC,TG,LDL- C in group 2 and 3 were significant higher than those of group 1 （P〈0. 01）, but they had not significant difference between group 2 and 3 （P〈0. 05）. The ratio of intima-media reduced obviously in group 3 than those of group 2 （P〈0. 05）. Conclusion These findings suggest that valsartan could affect the MCP-1 expression in experimental atherosclerotic rabbits which are probably related to its activating effect of PPARγ.

关 键 词：动脉粥样硬化 缬沙坦 过氧化物酶体增殖物激活受体Γ 单核细胞趋化蛋白-1 

分 类 号：R96[医药卫生—药理学]