复方甘草酸苷治疗儿童过敏性紫癜40例  

A clinical observation of compound glycyrrhizin injection in treatment of 40 children with henoch-schonlein purpura

作　　者：郭学鹏[1] 任喜凤[1] 赵洁玲[1] 

机构地区：[1]河南省辉县市人民医院,河南辉县453600

出　　处：《儿科药学杂志》2007年第4期61-62,共2页Journal of Pediatric Pharmacy

摘　　要：目的：探讨复方甘草酸苷治疗过敏性紫癜的临床疗效。方法：78例患儿随机分为治疗组40例和对照组38例,治疗组在常规治疗基础上加用复方甘草酸苷20-40mL/（kg.d）静脉滴注7-14d,并与对照组比较。结果：治疗组总有效率97.5%,对照组总有效率78.7%,两组比较差异有统计学意义（χ^2=4.88,P〈0.05）,治疗组皮肤、关节及消化道症状消退时间均短于对照组,两组比较t分别为8.21、5.21、12.4,P均〈0.01,差异均有统计学意义。结论：复方甘草酸苷辅佐治疗儿童过敏性紫癜,疗效肯定,可较快缓解症状及缩短病程,未见明显不良反应。Objective： To evaluate the clinical therapeutic effect of compound glycyrrhizin injection on children with Henech-Schonlein purpura （HSP）. Methods： The patients with HSP were randomly divided into two groups. 40 eases in the treatment group were treated with compound glycyrrhizin injection intravenously for 7 - 14 days in addition to the routine therapy and 34 eases in the control group with only routine therapy. Results： The over-all response rate was 97.5% in the treatment group and 78.7% in the control group, respectively （ P 〈 0.05）. The time for dispersion of skin, joint and gastrointestinal symptoms in the treatment group was shorter than that in the control group （ P 〈 0.01 ）, and the difference was significant. Conclusions： Compound glyeyrrhizin injection therapy is effective on children with HSP and it is helpful in shortening the period of progress, and ameliorating clinical symptoms without any side effects found.

关 键 词：复方甘草酸苷 过敏性紫疲 儿童 

分 类 号：R974[医药卫生—药品] R725.546[医药卫生—药学]