实验性兔动脉粥样硬化进程中全血粘弹性的变化及其临床意义  

CLINICAL SIGNIFICANCE OF CHANGES IN WHOLE BLOOD VISCOELASTICITY IN ATHEROSCLEROTIC RABBITS

作　　者：王红勇[1] 何作云[2] 李希楷[2] 丁秋华[2] 黄永萍[2] 

机构地区：[1]第三军医大学大坪医院心内科,重庆630042 [2]第三军医大学新桥医院心内科

出　　处：《中国血液流变学杂志》1997年第1期17-21,共5页Chinese Journal of Hemorheology

基　　金：国家自然科学基金资助课题(编号938800300)

摘　　要：经喂饲胆固醇饲料成功地复制了兔主动脉粥样硬化（ＡＳ）模型，并显示了ＡＳ脂纹期（早期）及ＡＳ纤维──粥样斑块期（晚期）的改变。在ＡＳ进程中呈现：（１）血清总胆固醇（Ｔｃｈ）浓度明显升高（Ｐ＜０．０１）；（２）红细胞膜钠泵活性渐降低（Ｐ＜０．０１）；（３）红细胞膜收缩蛋白（ＳＰ）相对含量下降（Ｐ＜０．０５～０．０１）；（４）全血粘弹性（动粘度η１和弹性模量Ｇ１）在ＡＳ晚期明显增高（Ｐ＜０．０５～０．０１）。Ｔｃｈ浓度与钠泵活性、ＳＰ含量间分别呈显著或非常显著负相关（ｒ＝－０．５１０７～－０．６７２１，Ｐ＜０．０５～０．０１； ｒ＝－０．７３０９～－０．７９４４，Ｐ＜０．０１）；钠泵活性与ＳＰ含量问呈显著或非常显著正相关（ｒ＝ ０．４７５０～０．５２９，Ｐ＜０．０５～０．０１）；Ｇ１与 ＳＰ含量间呈显著负相关（ｒ＝－ ０．４８３２～－ ０．６７１４，Ｐ＜０．０５～０．０１，但仅在高角频率时）；Ｇ１与η１呈显著或非常显著正相关（ｒ＝０．５１２７～０．８４８３，Ｐ＜０．０５～０．０１）。提示胆固醇浓度的升高与钠泵活性降低间有密切关联，而它们的改变与 ＳＰ含量降低有一定关系，并且上述三项因素的变化是全血粘弹性升高的重要原因。?To investigate the changes in serum cholesterol, erythrocyte membrance so- dium pump activity,the spectrin content and whole blood viscoelasticity in the course of atherosclerosis (AS ) in rabbits, 40 rabbits were given cholesterol lg/d in attempting to ob- tain an experirnental model of atheroscierosis. The results suggest hypercholesterolemia is associated with the decrease in erythrocytic membrance sodium pump activity, Hypercholesterolemia and dimmished activity of sodium pump are the important factors which result in the decrease of spectrin content and the alteration of the above three para- meters is responsible for the increase of whole blood viscoelasticity Finally,it is concluded that the increase of whole blood viscoelasticity plays an important role in the course of AS.

关 键 词：动脉粥样硬化 胆固醇 粘弹性 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]