过氧化氢在生成戊二酰-7-氨基头孢烷酸过程中的影响  

Effect of Hydrogen Peroxide on the Conversion to Glutaryl-7-ACA

作　　者：辛朝辉[1] 张彩娟[1] 朱科[1] 王俊英[1] 谭清钟 薛翰 王娜[2] 

机构地区：[1]石药集团河北中润制药公司研究所,河北石家庄050041 [2]河北医科大学基础科教学部,河北石家庄050091

出　　处：《河北化工》2007年第8期15-15,20,共2页Hebei Chemical Industry

摘　　要：头孢菌素C(CPC)在D-氨基酸氧化酶为催化剂的情况下,与O2反应生成α-ketoadipyl-7-ACA,再与过氧化氢反应生成戊二酰基-7-氨基头孢烷酸(Gl-7-ACA)。在此反应中生成的α-ketoadipyl-7-ACA是造成目标产物收率低的关键因素之一。通过加入适量的双氧水可以使剩余的α-ketoadipyl-7-ACA转化为Gl-7-ACA,从而使裂解的收率提高5%。Cephalosporin C was converted to a-ketoadipyl-7-ACA with 02,by B-amino acid oxidase （DAAO）, then was produced Glutaryl-7-ACA by adding hydrogen peroxide In this reaction α-ketoadipyl-7-ACA was one of the key factors which lead to low yield. Adding hydrogen peroxide properly, α-ketoadipyl-7-ACA could be mostly converted to Glutaryl-7-ACA. The yield was improved 5%.

关 键 词：D-氨基酸氧化酶(DAO) 过每化氢 戊二酰基-7-氨基头孢烷酸(G1-7-ACA) 

分 类 号：R978.11[医药卫生—药品]