旋光法测定头孢氨苄胶囊中头孢氨苄含量  

Determination of content of cefalexin capsules by polarimetric analysis

作　　者：张家明[1] 王丽琴[1] 

机构地区：[1]天津市药品检验所,天津300070

出　　处：《天津药学》2007年第4期9-10,共2页Tianjin Pharmacy

摘　　要：目的：建立快速测定头孢氨苄胶囊含量的方法。方法：以水为溶剂,采用旋光法测定头孢氨苄胶囊含量。结果：头孢氨苄在1.5-7.5 mg/ml范围内浓度与旋光度呈良好线性关系,回归方程C=-0.0012＋0.6877X（r=1.0000）,平均回收率100.2%,RSD为0.65%（n=9）。结论：本法简便易行,结果准确,可作为头孢氨苄胶囊的质控方法。OBJECTIVE To establish a method for determining the content of cefalexin capsules. METHODS Polarimetric analysis was used; and Water as solvent. RESULTS The linear range of cefalexin was 1.5 - 7.5 mg/ml. The regression equation C = -0. 001 2 ＋0. 687 7 X （r = 1. 000 0） ; the average rate of recovery was 100.2% ; RSD 0.65%. CONCLUSION The method was convenient, accurate and reliable. It was therefore suitable for the quality control of cefalexin capsules.

关 键 词：旋光法 头孢氨苄胶囊 含量测定 

分 类 号：R927.2[医药卫生—药学]