2-硝基苯基苯并咪唑衍生物微波合成  

Microwave synthesis of 2-nitrophenzyl-benzimidazole derivatives

作　　者：刘波[1] 吕维忠[1] 吴奕光[1] 韦少慧[1] 刘剑洪[1] 

机构地区：[1]深圳大学化学与化工学院,深圳518060

出　　处：《深圳大学学报（理工版）》2007年第3期309-312,共4页Journal of Shenzhen University(Science and Engineering)

摘　　要：在微波辐射下,以乙醇为溶剂,以邻苯二胺和硝基苯甲醛为原料,合成3种2-硝基苯基苯并咪唑.利用正交法优化微波促进该反应工艺条件,优化工艺参数为n(邻苯二胺)∶n(硝基苯甲醛)=1.2∶1.0,微波辐射温度为58℃,微波辐射20min.在优化条件下产率达81.2%,产物经熔点测试,采用IR和1HNMR进行表征确认.2-nitrophenzyl-benzimidazole was synthesized by the reaction of o-phenylenediamine with nitro-benaldehyde which was accelerated by microwave irradiation and ethyl alcohol as solvent. The method of orthogonal experiment was used to optimize synthesis factors which affect the reaction： n （o-phenylenediamine） ： n （nitro benalde- hyde） = 1.2： 1.0, and the temperature of microwave irradiation 58℃, the time of microwave irradiation 20 min. Under the optimal condition, the highest yield of the title compound was a bout 81.2%. The samples synthesized were characterized by melting point determination, IR spectrogram,^1HNMR spectra.

关 键 词：微波合成 苯并咪唑衍生物 正交实验 有机合成 

分 类 号：O626.25[理学—有机化学]