系统性红斑狼疮患者骨钙素、肿瘤坏死因子和白介素8水平变化及与免疫功能的关系  

Discussion on Relationship between Immune Function and Changes of Asteocalcin,TNF-α and IL-8 in SLE

作　　者：郭小兵[1] 刘红春[1] 林新平[2] 王玉梅[3] 

机构地区：[1]郑州大学第一附属医院检验科,河南郑州450052 [2]郑州大学护理学院,450052 [3]西华县人民医院检验科

出　　处：《中国误诊学杂志》2007年第17期3947-3948,共2页Chinese Journal of Misdiagnostics

基　　金：河南省教育厅自然科学基金资助项目(编号:2004312005)

摘　　要：目的:探讨系统性红斑狼疮(SLE)患者治疗前后的骨钙素(BGP)、肿瘤坏死因子(TNF-α)、白介素8(IL-8)的水平变化及与其免疫功能的关系。方法:采用放免法及酶免法检测了45例SLE患者治疗前后血清BGP、TNF-α及IL-8含量,采用速率散射比浊法测定免疫球蛋白,并与30例正常体检者进行对照。结果:45例SLE患者(SLE组)BGP水平明显低于正常对照组,而TNF-α及IL-8水平明显高于正常对照组(P<0.01),而补体C3水平低下。结论:SLE患者经激素治疗后有骨丢失现象,TNF-α、IL-8及补体C3参与SLE疾病过程,与炎症及疾病活动性相关。Objective：To investigate the relationship between immune function and the changes of osteocalcin, TNF-α and IL-8 in difference cure period of systemic lupus lrythematosus （SLE）. Method：The study population included 45 patients with SLE and 30 control people. We detected the serum BGP,TNT-α and IL-8 by RIA and ELISA,and de-tected the immune globulin by immune rate nephelometry. Result：BGP and complement level in 45 patients with SLE was lower than control people,however, TNF-α and IL-8 level was higher than control team. Conclusion：We can ob-verse the bone loss in patients with SLE who are curing with hormone. The changes of osteocalcin TNF-α, C3 and IL-8 relate with the development and activity of SLE.

关 键 词：红斑狼疮 系统性/免疫学 骨钙素/分析 肿瘤坏死因子/分析 白细胞介素8/分析 

分 类 号：R593.2[医药卫生—内科学]