左旋布比卡因腰麻15例临床分析  

Clinical Analysis of 15 Cases of Levobupivacaine Spinal Anesthesia

作　　者：印武[1] 陈丽红[1] 熊桂林[1] 鲁竟[1] 田孝军[1] 黄启文[1] 

机构地区：[1]荆州市第二人民医院麻醉科,湖北荆州434000

出　　处：《药物流行病学杂志》2007年第4期205-206,209,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:评价0.5%左旋布比卡因重比重液腰麻的安全性和临床效果。方法:ASAI～Ⅱ级妇产科择期手术患者30例,随机分为左旋布比卡因组(L组)和布比卡因组(B组)。入室开放静脉通道,输注平衡液10 ml/kg,30 min输完后,选择L_(3～4)间隙用笔尖式腰硬联合穿刺针,先行硬膜外穿刺,成功后,刺入配置好的腰麻针,见脑积液流出后,用5 ml OT针筒以0.1 ml·S^(-1)的速度注入配制好的药物(0.75%左旋布比卡因或0.75%布比卡因2 ml+10%葡萄糖1 ml),退出腰麻针,改平卧位。观察麻醉起效时间、维持时间、运动阻滞和恢复时间、麻醉效果以及血压、心率的变化和不良反应。结果:L组的起效时间(82.61±22.10)S,B组的起效时间(59.30±21.50)S;5 min内SBP、DBP、HR的变化明显轻于B组;维持时间、运动阻滞和恢复时间及麻醉效果差异不显著。结论:0.5%L-Bup重比重液腰麻后能取得与0.5%Bup重比重液同样的麻醉效果,循环更稳定。0.5%L-Bup重比重液作为腰麻用药是安全可行的。Objective： To evaluate the clinical safety and effectiveness of heavy specific gravity levobupivacaine in spinal block. Method： 30 selective general surgical patients of ASA Ⅰ～Ⅱ in obstetrics and gynecology were randomly divided into levobupivacaine group （ L group） and bupivacaine group （ B group）. After opening the venous channel and transfusing equilibrium liquid 30 mins, the T 4 - 5 space was selected as the puncture site for the epidural puncture. The 2 medicaments were injected in the rate of 0.1 ml/s respectively. Then the anesthetizing onset time, maintenance time, time of motion blockade and restoration, effect of anesthesia, variations of blood pressure and heart rate and adverse drug reaction were observed. Result： The onset time was 82.61 ±22, 10 s in L group and 59.30 ±21,50s in B group, respectively. The variations of SBP, DBP and HR in L group were less than those in B group. There was no significant difference in the 2 groups in maintenance time, time of motion blockade and restoration and effect of anesthesia. Conclusion： Compared with bupivacaine, heavy specific gravity levobupivacaine can make the same anesthesia effect with a steadier blood circulation. The specific gravity levobupivacaine is a safe and feasible drug for spinal anesthesia.

关 键 词：左旋布比卡因 布比卡因 蛛网膜下腔阻滞 

分 类 号：R971.2[医药卫生—药品]