仙珍骨宝抗泼尼松致大鼠松质骨结构破坏的作用  

Antagonistic effect of Xiang-Zhen-Gu-Bao on cancellous bone structure destruction due to prednisone in rats

作　　者：张志平[1] 谢华[2] 吴铁[3] 崔燎[3] 李青南[3] 

机构地区：[1]广东医学院组胚教研室,广东湛江524023 [2]广东医学院解剖教研室 [3]广东医学院药理教研室

出　　处：《解剖学研究》2007年第4期253-255,267,共4页Anatomy Research

基　　金：广东省科技计划资助项目(2003C30501)

摘　　要：目的观察仙珍骨宝对糖皮质激素引起松质骨结构破坏的防治作用。方法选用3月龄SD雄性大鼠24只,随机分为对照组、激素组和治疗组。激素组用泼尼松4.5mg/kg灌胃,每周2次。治疗组给予100%仙珍骨宝5ml/kg,每周6次,持续90d。用骨组织形态计量学方法测算胫骨近端骨小梁的静态指标,并在扫描电镜下观察大鼠腰椎松质骨结构的改变。结果与正常组比较,激素组的大鼠胫骨的骨小梁的面积减少72.43%,骨小梁数目减少74.09%。腰椎的骨小梁变少,变细,断裂,连接不紧密,表面常见骨吸收形成的陷窝。治疗组大鼠胫骨骨小梁的面积比激素组增加179.70%,骨小梁数目增多187.60%。腰椎的骨小梁较粗大,排列整齐,连接紧密。结论仙珍骨宝能有效防止糖皮质激素所引起的松质骨三维结构的损害,保持骨的正常力学强度,避免骨折。Objective To observe the effect of Xiang-zhen-Gu-Bao on prednison-induced destruction of cancellous bone structure in rats. Methods Twenty-four 3-month-old male SD rats were randomly divided into the three groups of the control, the hormonal and the treatment group. The hormonal group was given prednisone 4.5 mg/kg twice a week, the treatment group was given Xiang-Zhen-Gu-Bao 5 ml/kg （100%） 6 days per week. After 90 day, the rats were killed. The cancellous bone at the fifth lumbar vertebral body of rats were observed with the use of scanning electron microscope （SEM）. Results In comparison with control rats, the trabecular bone of rats received prednisone were manifested with the thinning, roughening and lacunare of the Xurface. The trabecular bones of rats treated with Xiang-Zhen-Gu-Bao are thick, its arrange ment was in good order and connected each other closely. Conclusion Xiang-Zhen-Gu-Bao prevents that prednisone causes changes in the three dimensional structure in cancellous bone, keeps bone normal in the mechanical strength and avoids fracture.

关 键 词：仙珍骨宝 泼尼松 松质骨 骨质疏松 

分 类 号：R285.5[医药卫生—中药学]