口服重组GAD65蛋白延缓NOD小鼠Ⅰ型糖尿病发生  

Oral use of GAD65 porotein delays the onset of type Ⅰ diabetes mellitus in nonobese diabetic mice

作　　者：黄月玲[1] 郑小玲[2] 刘启才[1] 林勇平[1] 孙卫文[2] 陈盛强[2] 

机构地区：[1]广州医学院实验动物中心,广东广州510182 [2]广州医学院附属第二医院,广州510260

出　　处：《解剖学研究》2007年第4期279-280,284,共3页Anatomy Research

基　　金：广东省自然科学基金(No.04009574)

摘　　要：目的研究重组GAD65蛋白对NOD小鼠1型糖尿病的预防作用。方法6周龄NOD雌鼠1周3次灌胃重组GAD65蛋白,共32周,观测胰岛炎和糖尿病发病。结果重组GAD65蛋白能明显降低NOD小鼠糖尿病的发生和胰岛炎的严重程度。结论口服重组GAD65蛋白能预防NOD鼠糖尿病。Objective To explore the effect of GAD65 protein on delaying the onset of type Ⅰ diabetes in NOD mice. Methods Female NOD mice, 6 weeks old, were administered with GAD65 protein three times a week via gavage for 6 to 56 weeks. Results Administering GAD65 protein to female NOD mice could significantly suppress their diabetes and insulitis. Conclusion Oral use of GAD65 protein can prevent the NOD mice from suffering diabetes.

关 键 词：重组GAD65蛋白 Ⅰ型糖尿病 NOD小鼠 

分 类 号：R587.1[医药卫生—内分泌]